Ibuprofen is a Class II Biological Safety Class(BSC)drugs used for relief of arthritis,as an analgesic and possesses the effect of antiplatelet.The major problem involves in ibuprofen is it has a low solubility and high permeability thus causes an unsatisfactory therapeutic effect to humans.Thus,in this work,alteration of ibuprofen’s physicochemical properties is conducted by means of cocrystallization technique.Co-crystallizations of ibuprofen were prepared with selected coformers using dry grinding and liquid assisted grinding(LAG)techniques in different molar ratios while ethanol and propanol were used as a solvent.The new crystalline forms were identified and characterized by differential scanning,calorimetry(DSC),powder X-ray diffraction(PXRD)and fourier transform infrared spectroscopy(FTIR).Analysis for Ibuprofen-Citric acid(IBP-CA)system,co-crystal was successfully formed in 1:2,1:3,2:1 and 3:1 molar ratios for neat grinding method although the co-crystal produced is unstable.Meanwhile,for Ibuprofen-Oxalic acid(IBP-OA)system,the co-crystal formation was identified only in 1:1,1:2 and 1:3 molar ratios for the neat grinding method.LAG method shows that co-crystal formation was unsuccessful in both solvents for IBP-CA,while IBP-OA co-crystal was formed in the molar ratio 1:1,2:1 and 3:1 in ethanol,and 2:1 and 3:1 in propanol.
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