Objective: To study the effect of Modified Dachengqi decoction and Dachengqi decoction on gastrointestinal motility in dyspepsia mice. Method: Mice were randomly divided into 5 groups: control group (normal saline), model group (normal saline), Dachengqi decoction group (0.054 g kg-1), Modified Dachengqi decoction group (0.084g kg-1) and Motilium group (0.17 ml kg-l).Result:Compared with the normal group, the myenteric tension of small intestine increased significantly, and the small intestine propulsion rate decreased significantly (P < 0.05).Compared with the model group, the myenteric tension of small intestine in Dachengqi decoction group decreased significantly (P < 0.05), the myenteric tension of small intestine muscle in Modified Dachengqi decoction group decreased significantly, and the small intestinal propulsion rate increased significantly (P < 0.01). And in these two groups, the serum MDA levels decreased significantly, and the serum SOD activity increased significantly (P < 0.01).Conclusion: Modified Dachengqi decoction can improve gastrointestinal stagnation in dyspepsia mice, and its mechanism may be related to the regulation of oxidative stress in dyspepsia mice.
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机译：目的：探讨改良达峰汤汤和大成汤汤对消化不良小鼠胃肠运动的影响。方法：将小鼠随机分为5组：对照组（生理盐水），模型组（正常盐水），达格QI煎剂组（0.054克KG-1），改性的大叉Qi煎剂组（0.084g Kg-1）和运动组（ 0.17 ml kg-l）。结果：与正常组相比，小肠的神心张力显着增加，小肠的推进率显着下降（p <0.05）。与模型组的分化，小肠的神经元张力在达格QI汤剂集团明显下降（P <0.05），修饰的大叉QI煎剂组中小肠肌的神心张力显着下降，小肠推进率显着增加（P <0.01）。在这两组中，血清MDA水平显着下降，血清SOD活性显着增加（P <0.01）。结论：改性的大叉汤汤可以改善消化不良小鼠的胃肠道停滞，其机制可能与氧化的调节有关。其机制可能与氧化的调节有关在消化不良小鼠中的应激。
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