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PLA-based foams as scaffolds for tissue engineering applications

机译：基于PLA的泡沫作为组织工程应用的支架

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In this work a simple, innovative, low-cost methodology was developed to produce PLA-based foams with good physico-mechanical properties and well interconnected open-pores in absence of organic solvents and chemical foaming agents. At first biocomposites were prepared by melt-blending crosslinked particles of sodium polyacrylate, commonly used as superabsorbent polymer (SAP), and poly-L-lactic acid based matrices (PLA). Morphological analyses showed a biphasic system with a regular distribution of particles, with diameters up to about 50 μm, within the PLA based matrices. The mechanical properties of PLA based matrices, dependent on biomaterial compositions, are markedly modified by addition of crosslinked particles, revealing by a regular stiffening effect. In addition, the polymeric biphasic system showed excellent swelling properties, demonstrating that cross-linked particles retain their superabsorbent ability even if distributed in a thermoplastic polymeric matrix. Subsequently, in aqueous environments the particles swell and are leached from PLA based matrices generating very high porosity. The new open-pore biomaterials allowed good cell adhesion and proliferation during culture of rat myoblasts cell lines. Hence this procedure, in general applicable not only to PLA-based polymeric systems but also to other biocompatible polymers, is suitable to selectively modify biomaterial properties and appear very promising for several applications, in particular for scaffold production in tissue engineering.
机译：在这项工作中，开发了一种简单，创新的低成本方法，以生产基于PLA的泡沫，具有良好的物理 - 机械性能，并且在没有有机溶剂和化学发泡剂的情况下良好的互连开孔。在第一生物复合材料中通过熔融混合的聚丙烯酸钠的交联颗粒制备，通常用作超吸收性聚合物（SAP）和聚-L-乳酸基基质（PLA）。形态学分析显示了一种双相系统，其具有常规分布的颗粒，直径高达约50μm，在PLA基质内。通过加入交联颗粒，通过加入交联颗粒来显着改性PLA基质基质的力学性质，通过常规加强效应显示。此外，聚合物双相系统显示出优异的溶胀性能，证明交联颗粒即使在热塑性聚合物基质中分布也保持其超吸收性能力。随后，在水性环境中，颗粒溶胀并从基于PLA的基质浸出产生非常高的孔隙率。新的开放式生物材料允许大鼠肌细胞细胞系培养过程中良好的细胞粘附和增殖。因此，通常不仅适用于基于PLA的聚合物系统，还适用于其他生物相容性聚合物，适用于选择性地改变生物材料性质，并且对于几种应用看起来非常有前途，特别是用于组织工程中的支架生产。

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