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首页> 外文会议>Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies >Optoelectronical methods for screening of Pralmorelin and its metabolite in urine samples
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Optoelectronical methods for screening of Pralmorelin and its metabolite in urine samples

机译：用于筛选尿素样品的孕素及其代谢物的光电子方法

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摘要

GHRP-2, also known as Pralmorelin, is a synthetic peptide drug. It acts as ghrelin/growth-hormone secretagogue receptor agonist, being the first drug of this class introduced clinically. It's used, in a single dose formulation, as a diagnostic agent for growth hormone deficiency (GHD). Administration of GHRP-2 increases the plasmatic concentration of growth hormone. It was clinically tested for tratment of GHD and pituitary dwarfism. GHRP-2 has performance enhancing potential and is prohibited for athletes in section S2: Peptide Hormones, Growth Factors, Related Substances, And Mimetics of WADA (World Antidoping Agency) Prohibited List. In this work we developed and validated a screening method for GHRP-2 and it's two metabolites from urine on LC-HRMS (liquid chromatography coupled with high resolution mass spectrometry)(Q Exactive Plus from Thermo Scientific) and LC-MS/MS triple quadrupole (liquid chromatography coupled with mass spectrometry) (ABSciex QTrap 5500). The validation parameters evaluated were limit of detection, matrix effects, identification criteria, specificity, carry-over and extraction recovery. the evaluated parameters are in accordance with WADA technical documents, both methods being applicable for doping control application.
机译：GHRP-2，也称为Pralmorelin，是一种合成肽药物。它充当Ghrelin /生长激素促泌乳受体激动剂，是本课程的第一个药物临床介绍。它在单一剂量配方中使用，作为生长激素缺乏（GHD）的诊断剂。 GHRP-2的给药增加了生长激素的血浆浓度。它在临床测试中测试了GHD和垂体侏儒症的兄弟。 GHRP-2具有绩效增强潜力，并禁止S2部分运动员：WADA（世界抗动机构）禁止名单的肽激素，生长因子，相关物质和模仿。在这项工作中，我们开发并验证了GHRP-2的筛选方法，它是来自LC-HRMS的尿液中的两个代谢物（液相色谱与高分辨率质谱）（Q从Thermo Sciencific耦合）和LC-MS / MS三重四极（液相色谱与质谱耦合）（Absciex Qtrap 5500）。评估的验证参数是检测限制，矩阵效应，识别标准，特异性，携带和提取恢复。评估的参数符合Wada技术文件，这两种方法都适用于掺杂控制应用。

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