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首页> 外文会议>International Conference on Materials Engineering and Science >Porous silicon nanoparticles prepared via an improved method: a developing strategy for a successful antimicrobial agent against Escherichia coli and Staphylococcus aureus
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Porous silicon nanoparticles prepared via an improved method: a developing strategy for a successful antimicrobial agent against Escherichia coli and Staphylococcus aureus

机译：通过改进的方法制备多孔硅纳米颗粒：对大肠杆菌和金黄色葡萄球菌的成功抗微生物剂的发育策略

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One of the commonest nanoparticles with unique properties is porous silicon nanoparticles (PSNPs). This study aims to prepare PSNPs via an improved method, followed by the investigation of the antimicrobial activity of the synthesized PSPNs against Escherichia coli and Staphylococcus aureus. The synthesis of the PSNPs was executed via a modified electrochemical etching process. After the synthesis, the obtained liquid PSNPs were subjected to laser treatment under an Nd-YAG laser condition of laser energy 350 mJ, and wavelength 1064 nm. The synthesized PSNPs were further characterized for functional groups and surface morphology using Fourier transfer infrared (FTIR) and Scanning Electron Microscopy (SEM), respectively. With E. coli and S. aureusas the commonest implicated organisms in both adult and childreninfections,there is a need to explore novel antimicrobial agents rather than antibiotics for curtailing these bacterial species. The synthesized PSNPs showed potential antibacterial activity against the studied organisms, although the observed antibacterial activities after the combination of PSNPs with Amoxicillin and Cephalexin were higher compared to the activity of PSNPs alone. These complexes were observed to act on the bacterial cytoplasmic membrane and nucleic acid which resulted in an improved cellular permeability due to the loss of membrane integrity and nucleic acid damage. However, there is a need to further investigate the antibacterial activity of PSNPs and its complexes with other antibacterial agents against other disease-causing by other bacterial species. Keyword: Porous silicon nanoparticles; Antimicrobial activity; improved electrochemical etching; FTIR; SEM.
机译：具有独特性质的最常见的纳米颗粒是多孔硅纳米颗粒（PSNP）。本研究旨在通过改进的方法制备PSNP，然后调查合成的PSPNS对大肠杆菌和金黄色葡萄球菌的抗菌活性。通过改进的电化学蚀刻工艺执行PSNP的合成。在合成之后，在激光能量350mJ的Nd-YAG激光条件下，将所得液体PSNPS进行激光处理，波长为1064nm。通过傅里叶转移红外（FTIR）和扫描电子显微镜（SEM），进一步表征合成的PSNP分别用于官能团和表面形态学。对于大肠杆菌和金黄色葡萄球菌，在成人和儿童抚养中最常见的牵种生物，需要探索新的抗微生物剂，而不是抗生素来限制这些细菌种类。合成的PSNP表明，对研究的生物体潜在的抗菌活性，尽管与单独的PSNPS的活性相比，观察到PSNP与阿莫西林和头孢菌素的组合后观察到的抗菌活性。观察到这些复合物作用于细菌细胞质膜和核酸，导致由于膜完整性和核酸损伤的损失而导致细胞渗透性的改善。然而，需要进一步研究PSNP的抗菌活性及其与其他抗菌剂对其他细菌物种引起的其他抗菌剂的抗菌活性。关键词：多孔硅纳米粒子;抗菌活性;改进电化学蚀刻; FTIR; SEM。

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