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Experimental study on skin irritation of bone spur powder on rabbit

机译：兔骨刺粉皮肤刺激的实验研究

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To observe the effect of bone powder of rabbit skin, provide the basis for the safety of clinical use of bone powder, 24 rabbits were randomly divided into 6 groups, complete skin test and damaged skin test each divided into 3 groups (n=4), high, low, 3 doses tested daily administered 1 times, continuous administration for 7 days, in 24 hours after the last administration of drug residues, wash with warm water, the removal of L hours after drug for 24 hours, 48 hours, 72 hours and seventh days, observed and recorded to apply position before administration and administration during the skin no erythema and edema, and observe the smear Parts of any pigmentation, bleeding, rough skin or thin skin etc., record the occurrence time and duration time. Through comparative observation, intact skin group before administration and dosing period, there were no erythema and edema, pigmentation, bleeding, rough skin or thin skin etc., there is no difference with the control group; the damaged skin group after administration of 1 to 5 days, each rabbit skin there are different degrees of erythema and edema, especially to skin injury after 24-48 hours is obvious, 2 days (48 hours) after 4 days gradually reduced, significantly subsided after 6 days, erythema and edema phenomenon subsided completely, not out of blood, pigmentation, rough skin or thin skin and so on. The bone spur powder has no irritation on the intact skin of rabbits. The bone spur powder has moderate irritation on the damaged skin of rabbits, but after 48 hours, the stimulation reaction subsided spontaneously, which is caused by the inflammatory reaction caused by skin injury, rather than
机译：要观察兔皮肤骨粉的效果，为临床使用的骨粉安全为基础，将24只兔子随机分为6组，完整的皮肤测试和受损的皮肤测试各分为3组（n = 4） ，高，低，3剂试验日常施用1次，连续给药7天，在最后一次施用药物残留后24小时，用温水洗涤，药物后去除药物后24小时，48小时，72小时。小时和第七天，观察并记录皮肤无红斑和水肿期间应用管理和给药前的位置，观察任何色素沉着的涂抹部位，出血，皮肤粗糙或皮肤薄等，记录发生时间和持续时间。通过对比观察，完整的皮肤组在给药前，没有红斑和水肿，色素沉着，出血，粗糙的皮肤或薄皮肤等，对照组没有区别;施用1至5天后受损的皮肤组，每只兔皮肤有不同程度的红斑和水肿，特别是皮肤损伤24-48小时明显，2天（48小时）逐渐减少，显着消退6天后，红斑和水肿现象完全消退，不是出血，色素沉着，粗糙的皮肤或薄皮等。骨穗粉对兔的完整皮肤没有刺激。骨穗粉对兔子受损的皮肤中等刺激，但在48小时后，刺激反应自发地枯竭，这是由皮肤损伤引起的炎症反应引起的，而不是

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