Progress of JAK/STAT 3 and its Inhibitors in the Treatment of Cancer

机译：JAK / Stat 3及其抑制剂在治疗癌症中的进展

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Signal Transducers and Activators of Transcription 3 (STAT3) is an important transcription factor in cells, which can be phosphorylated and activated by its most common upstream kinase, JAK kinase in vivo. It is well known that abnormally activated STAT3 promotes tumorigenesis and development of tumors. Therefore, the authors collected research and clinical studies on inhibitors targeting JAK / STAT3 signaling pathways reported in recent literature. The progress of the experiment is summarized in the target, mechanism of action and pharmacodynamic activity that have been reported for some inhibitors.

机译：信号传感器和转录3（STAT3）的激活剂是细胞中的重要转录因子，其可以通过其最常见的上游激酶，体内磷酶磷酸化和活化。众所周知，异常活化的STAT3促进肿瘤的肿瘤引发和发育。因此，作者收集了旨在瞄准jak / stat3信号传导途径的抑制剂研究和临床研究。实验的进展总结在靶向某些抑制剂的作用机制和药效学活动中。

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《International Conference on Frontiers of Biological Sciences and Engineering》|2020年|1 volume (various pagings) :|共7页
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作者
Wanting Hu;
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中图分类 Q81-532;
关键词
JAK; STAT 3; Tumor; Targeted therapy; Inhibitors;

机译：jak;stat 3;肿瘤;靶向治疗;抑制剂;

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专利

1. MOMELOTINIB HYDROCHLORIDE JAK1/JAK2 inhibitor Treatment of myelofibrosis Treatment of pancreatic cancer [J] . Price S., George T., Pinilla-Ibarz J. Drugs of the Future . 2015,第9期

机译：盐酸莫美洛尼布JAK1 / JAK2抑制剂治疗骨髓纤维化治疗胰腺癌
2. AZD1480, a JAK inhibitor, inhibits cell growth and survival of colorectal cancer via modulating the JAK2/STAT3 signaling pathway [J] . Wang Shu-Wei, Hu Jun, Guo Qin-Hao, Oncology reports . 2014,第5期

机译：JAK抑制剂AZD1480通过调节JAK2 / STAT3信号通路抑制大肠癌的细胞生长和存活
3. Pharmacologic Suppression of JAK1/2 by JAK1/2 Inhibitor AZD1480 Potently Inhibits IL-6-Induced Experimental Prostate Cancer Metastases Formation [J] . Gu Lei, Talati Pooja, Vogiatzi Paraskevi, Molecular cancer therapeutics . 2014,第5期

机译：JAK1 / 2抑制剂AZD1480对JAK1 / 2的药理抑制作用有效抑制IL-6诱导的实验性前列腺癌转移的形成。
4. Progress of JAK/STAT 3 and its Inhibitors in the Treatment of Cancer [C] . Wanting Hu International Conference on Frontiers of Biological Sciences and Engineering . 2020

机译：JAK / Stat 3及其抑制剂在治疗癌症中的进展
5. Transcriptional and Proteomic Changes Associated with the Sensitivity and Resistance to JAK2 Inhibitors: Implications for the Treatment of BCR-ABL (-) Myeloproliferative Neoplasms (MPNs). [D] . McDevitt, Theresa Marie. 2012

机译：与JAK2抑制剂的敏感性和抗性相关的转录和蛋白质组学变化：对BCR-ABL（-）骨髓增生性肿瘤（MPNs）的治疗意义。
6. PHARMACOLOGICAL SUPPRESSION OF JAK1/2 BY JAK1/2 INHIBITOR AZD1480 POTENTLY INHIBITS IL-6-INDUCED EXPERIMENTAL PROSTATE CANCER METASTASES FORMATION [O] . Lei Gu, Pooja Talati, Paraskevi Vogiatzi, -1

机译：JAK1 / 2抑制剂AZD1480对JAK1 / 2的药理学抑制作用有力地抑制了IL-6诱导的实验性前列腺癌转移的形成。
7. Phlorizin from sweet tea inhibits the progress of esophageal cancer by antagonizing the JAK2/STAT3 signaling pathway [O] . Zhenxian Jia, Yuning Xie, Hongjiao Wu, 2021

机译：来自甜茶的甘油蛋白通过拮抗JAK2 / Stat3信号通路来抑制食道癌的进展

Progress of JAK/STAT 3 and its Inhibitors in the Treatment of Cancer

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