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首页> 外文会议>Conference on Single Molecule Spectroscopy and Imaging >Single molecule detection for in vitro diagnostics
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Single molecule detection for in vitro diagnostics

机译：体外诊断的单一分子检测

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摘要

In this paper we present a novel highly sensitive detection system for diagnostic applications. The system is designed to meet the needs of medical diagnostics for reliable measurements of pathogens and biomarkers in the low concentration regime. It consists of a confocal detection unit, micro-structured sampling cells, and a "Virtual lab" analysis software. The detection unit works with laser induced fluorescence and is designed to provide accurate and highly sensitive measurement at the single molecule level. Various sampling cells are micro-structured in glass, silicon or polymers to enable measurements under flow and nonflow conditions. Sampling volume is below one microliter. The ,,"Virtual lab" software analyzes the light intensity online according to the patent pending "Accurate Stochastic Fluorescence Spectroscopy" (ASFS) developed by FluIT Biosystems GmbH. Tools for simulation and experiment optimization are included as well. Experimental results for various applications with relevance for in vitro diagnostics will be presented.
机译：在本文中，我们提出了一种用于诊断应用的新型高敏感检测系统。该系统旨在满足医疗诊断的需求，以获得低浓度制度的可靠测量病原体和生物标志物。它由共聚焦检测单元，微结构化采样单元和“虚拟实验室”分析软件组成。检测单元适用于激光诱导的荧光，设计用于在单个分子水平下提供精确且高灵敏度的测量。各种采样细胞在玻璃，硅或聚合物中是微结构，以在流动和非流动条件下进行测量。采样量低于一个微升。 “虚拟实验室”软件根据面板BioSystems GmbH开发的“精确随机荧光光谱”（ASF）分析在线的光强度。还包括用于仿真和实验优化的工具。展示了各种应用的实验结果，将介绍具有体外诊断的各种应用。

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