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首页> 外文会议>Conference on Single Molecule Spectroscopy and Imaging; 20080119-21; San Jose,CA(US) >Single molecule detection for in vitro diagnostics
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Single molecule detection for in vitro diagnostics

机译：单分子检测用于体外诊断

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摘要

In this paper we present a novel highly sensitive detection system for diagnostic applications. The system is designed to meet the needs of medical diagnostics for reliable measurements of pathogens and biomarkers in the low concentration regime. It consists of a confocal detection unit, micro-structured sampling cells, and a "Virtual lab" analysis software. The detection unit works with laser induced fluorescence and is designed to provide accurate and highly sensitive measurement at the single molecule level. Various sampling cells are micro-structured in glass, silicon or polymers to enable measurements under flow and nonflow conditions. Sampling volume is below one microliter. The ,,"Virtual lab" software analyzes the light intensity online according to the patent pending "Accurate Stochastic Fluorescence Spectroscopy" (ASFS) developed by FluIT Biosystems GmbH. Tools for simulation and experiment optimization are included as well. Experimental results for various applications with relevance for in vitro diagnostics will be presented.
机译：在本文中，我们提出了一种用于诊断应用的新型高灵敏度检测系统。该系统旨在满足医学诊断的需求，以便在低浓度条件下可靠地测量病原体和生物标志物。它由共聚焦检测单元，微结构化采样池和“虚拟实验室”分析软件组成。该检测单元与激光诱导的荧光一起工作，旨在提供单分子水平的准确和高度灵敏的测量。各种采样单元在玻璃，硅或聚合物中微结构化，从而能够在流动和非流动条件下进行测量。采样量低于一微升。 “虚拟实验室”软件根据FluIT Biosystems GmbH开发的正在申请专利的“精确随机荧光光谱法”（ASFS）在线分析光强度。还包括用于仿真和实验优化的工具。将介绍与体外诊断相关的各种应用的实验结果。

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