首页> 外文会议>V Latin American Congress on Biomedical Engineering >Modelo Biofisico de la Dinamica Neuronal del Circuito Motor en la Seleccion de una Accion Basado en Estudios de Resonancia Magnetica Nuclear
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Modelo Biofisico de la Dinamica Neuronal del Circuito Motor en la Seleccion de una Accion Basado en Estudios de Resonancia Magnetica Nuclear

机译:基于核磁共振研究的动作选择的电动机电路的神经元动力学的生物学模型

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Formulation of models describing the participation of the basal ganglia (GB) in action selection is limited by suppositions and simplifications necessary to replicate the biological system properties. However, the study of functional connectivity by functional magnetic resonance (RMNf), allow us to characterize the dynamics of the GB-thalamus-cortex circuitry. The aim of the present work is to simulate the GB-thalamus-cortex circuitry interaction in motor program selection, supported by functional connectivity pattern obtained by RMNf. Determination of connections weights between neural populations by RMNf, contributed to a more realistic formulation of the model and allowed to describe the participation of the GB in motor program selection and the changes in Parkinson disease. The simulation allowed to demonstrate that a dopamine depletion upper to 40% leads to a loss of action selection ability.
机译:用于描述基础神经节(GB)在动作选择中的参与的模型的配方受到复制和简化以复制生物系统性质所需的限制。然而,通过功能磁共振(RMNF)的功能连通性研究允许我们表征GB-Thalamus-Cortex电路的动态。本作工作的目的是模拟电机程序选择中的GB-Thalamus-Cortex电路交互,由RMNF获得的功能连接模式支持。 RMNF确定神经群之间的连接权重,促进了模型的更现实的制定,并允许描述GB在电机程序选择中的参与以及帕金森病的变化。允许模拟表明,多巴胺耗尽较高至40%导致动作选择能力的损失。

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