Control of T cell tolerance by phosphatase and tensin homolog

机译：通过磷酸酶和张素同源物控制T细胞耐受性

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The in vivo maintenance of immune tolerance is critically dependent on regulatory T (T_(reg)) cells, a lineage of CD4~+ T cells expressing the transcription factor Foxp3 that exerts immunoregulatory function. Because of the potential benefit of using Treg cells for cellular immunotherapy in clinical settings, including autoimmune disease and transplantation,much attention has been directed at understanding the signals that govern Treg cell development, function, and homeostasis. Studies with genetically modified mouse models have shown that the lipid phosphatase PTEN (phosphatase and tensin homolog), the predominant negative regulator of the PI3K/Akt pathway in T cells, hasmultiple functions in sustaining T cell–mediated immune tolerance in vivo. In addition to its role in maintaining T cell homeostasis, the PI3K/Akt pathway also has an essential role in T cell development and lineage commitment, contributing to the cell fate decision between conventional and regulatory T cells

机译：体内维持免疫耐受性均可致依赖于调节性T（T_（reg））细胞，CD4〜+ T细胞的谱系表达施加免疫调节功能的转录因子Foxp3。由于使用Treg细胞在临床环境中使用Treg细胞进行细胞免疫疗法的潜在益处，包括自身免疫性疾病和移植，因此在理解Treg细胞发育，功能和稳态的信号方面旨在很多。具有基因改性小鼠模型的研究表明，脂质磷酸酶PTEN（磷酸酶和Tensin Homolog），T细胞中PI3K / AKT途径的主要负调节剂，具有多种功能在维持体内的T细胞介导的免疫耐受性。除了在维持T细胞稳态方面的作用外，PI3K / AKT途径还具有在T细胞开发和血统承诺中具有重要作用，有助于常规和调节T细胞之间的细胞命运决策

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《Inositol Phospholipid Signaling in Physiology and Disease (Conference)》|2013年||共3页
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Alexandria Huynh; Laurence A. Turka;
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中图分类 58.174234083;
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T cells; tolerance; PI3K; PTEN; regulatory T cell;

机译：T细胞;耐受性;PI3K;PTEN;监管T细胞;

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1. Control of T cell tolerance by phosphatase and tensin homolog [J] . Alexandria Huynh, Laurence A. Turka Annals of the New York Academy of Sciences . 2013,第期

机译：通过磷酸酶和张力蛋白同源物控制T细胞耐受性
2. Loss of phosphatase and tensin homolog (PTEN) in myeloid cells controls inflammatory bone destruction by regulating the osteoclastogenic potential of myeloid cells [J] . Blueml Stephan, Friedrich Martin, Lohmeyer Tobias, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2015,第1期

机译：髓样细胞中磷酸酶和张力蛋白同源物（PTEN）的丧失通过调节髓样细胞的破骨细胞潜力来控制炎症性骨破坏
3. beta-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models [J] . Goiran Thomas, Duplan Eric, Chami Mounia, Biological psychiatry . 2018,第5期

机译：β-淀粉样蛋白前体蛋白细胞内结构域通过调节磷酸酶和三素同源物诱导的细胞中的激酶1转录和阿尔茨海默氏手术模型来控制线粒体功能
4. Control of T cell tolerance by phosphatase and tensin homolog [C] . Alexandria Huynh, Laurence A. Turka Inositol Phospholipid Signaling in Physiology and Disease (Conference) . 2013

机译：通过磷酸酶和张素同源物控制T细胞耐受性
5. The impact of E-cadherin and phosphatase and tensin homolog ablation in the uterus: The progression of type I endometrial carcinoma. [D] . Lindberg, Mallory Elisabeth. 2014

机译：E-钙黏着蛋白，磷酸酶和张力蛋白同源物消融对子宫的影响：I型子宫内膜癌的进展。
6. Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis [O] . Stephan Blüml, Emine Sahin, Victoria Saferding, 2015

机译：抗原呈递细胞中的磷酸酶和张力蛋白同源物（PTEN）控制Th17介导的自身免疫性关节炎
7. Loss of phosphatase and tensin homolog (PTEN) in myeloid cells controls inflammatory bone destruction by regulating the osteoclastogenic potential of myeloid cells [O] . Stephan Blüml, Martin Friedrich, Tobias Lohmeyer, 2013

机译：骨髓细胞中磷酸酶和苔藓素同源物（PTEN）的损失通过调节骨髓细胞的骨细胞源性潜力来控制炎症骨破坏

Control of T cell tolerance by phosphatase and tensin homolog

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