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首页> 外文期刊>Annals of the New York Academy of Sciences >Control of T cell tolerance by phosphatase and tensin homolog
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Control of T cell tolerance by phosphatase and tensin homolog

机译：通过磷酸酶和张力蛋白同源物控制T细胞耐受性

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摘要

The in vivo maintenance of immune tolerance is critically dependent on regulatory T (T_(reg)) cells, a lineage of CD4~+ T cells expressing the transcription factor Foxp3 that exerts immunoregulatory function. Because of the potential benefit of using T_(reg) cells for cellular immunotherapy in clinical settings, including autoimmune disease and transplantation, much attention has been directed at understanding the signals that govern T_(reg) cell development, function, and homeostasis. Studies with genetically modified mouse models have shown that the lipid phosphatase PTEN (phosphatase and tensin homolog), the predominant negative regulator of the PI3K/Akt pathway in T cells, has multiple functions in sustaining T cell-mediated immune tolerance in vivo. In addition to its role in maintaining T cell homeostasis, the PI3K/Akt pathway also has an essential role in T cell development and lineage commitment, contributing to the cell fate decision between conventional and regulatory T cells.
机译：体内免疫耐受的维持至关重要地依赖于调节性T（T_（reg））细胞，这是CD4〜+ T细胞的一种谱系，其表达具有免疫调节功能的转录因子Foxp3。由于在临床环境中使用T_（reg）细胞进行细胞免疫治疗（包括自身免疫性疾病和移植）具有潜在的益处，因此，许多注意力都集中在理解控制T_（reg）细胞发育，功能和体内平衡的信号上。对转基因小鼠模型的研究表明，脂质磷酸酶PTEN（磷酸酶和张力蛋白同源物）是T细胞中PI3K / Akt途径的主要负调节剂，在维持体内T细胞介导的免疫耐受性方面具有多种功能。除了在维持T细胞稳态中的作用外，PI3K / Akt途径在T细胞发育和谱系承诺中也起着至关重要的作用，有助于常规T细胞和调节性T细胞之间的细胞命运决定。

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