Immunogenicity of a Polyinosinic-Polycytidylic Acid (Poly(I:C))-Adjuvanted Microparticle Vaccine for Leishmaniasis

机译：多胞聚环酸的免疫原性（Poly（I：C）） - LeishManiaisis的佐剂微粒疫苗

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Results showed that PICL enhanced the T_H1-associated IgG2a and IgG2b titers, and also increased splenocyte IFN-γ production. In comparison to the soluble NH36/PICL group, microparticle formulation significantly increased T_H1-biased cellular immune responses as evidenced by higher frequency of IFNγ-producing cells and higher total secreted IFN-γ. These results indicate a strong potential for the MP/PICL combination as an adjuvant/delivery system for a Leishmania protein vaccine.

机译：结果表明，PICL增强了T_H1相关的IgG2A和IgG2B滴度，也增加了脾细胞IFN-γ产生。与可溶性NH 36 / PICL组相比，微粒制剂显着增加了T_H1偏置的细胞免疫应答，如IFNγ产生细胞的较高频率和更高的IFN-γ所证明。这些结果表明MP / PICL组合作为LeishMania蛋白疫苗的辅助/送给系统的强大潜力。

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《Society for Biomaterials Annual Meeting and Exposition》|2015年||共1页
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Qian Wang; Meagan A. Barry; Christopher A. Seid; Elissa M. Hudspeth; Charles P. McAtee; Michael J. Heffernan;
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4. Immunogenicity of a Polyinosinic-Polycytidylic Acid (Poly(I:C))-Adjuvanted Microparticle Vaccine for Leishmaniasis [C] . Qian Wang, Meagan A. Barry, Christopher A. Seid, Society for Biomaterials Annual Meeting and Exposition . 2015

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Immunogenicity of a Polyinosinic-Polycytidylic Acid (Poly(I:C))-Adjuvanted Microparticle Vaccine for Leishmaniasis

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