• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Annual Conference of the New Zealand Society of Animal Production >Preliminary linkage studies in sheep of keratin and keratin-associated protein genes with fleece weight, wool fibre diameter and fibre curvature
【24h】

Preliminary linkage studies in sheep of keratin and keratin-associated protein genes with fleece weight, wool fibre diameter and fibre curvature

机译：角蛋白和角蛋白相关蛋白基因绵羊绵羊的初步联系研究，羊毛纤维直径和纤维曲率

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A linkage study was conducted to detect variations in the genes for keratins and keratin-associated proteins (KRTAP) that might affect wool traits. To date 93 such genes have been identified in sheep: 85 of them (-91%) are clustered in three chromosomal regions. Twenty-one genes are grouped within a 4-Mbp region on sheep chromosome 1 (OAR1), 28 within a 1-Mbp segment on chromosome 3 (OAR3), and 36 are clustered within a 1.3-Mbp site on chromosome 11 (OAR11). The DNA markers used in this work were single nucleotide polymorphisms (SNPs) dispersed throughout these keratin and KRTAP gene clusters. Markers were designed as three SNP-multiplexes: a 25-SNP, a 15-SNP and a 19-SNP multiplex for keratins/KRTAP regions on OAR1, OAR3 and OAR11, respectively. Resource animals came from eleven sire families whose progeny had been phenotyped for greasy fleece weight, washing yield, fibre curvature and diameter. Between 29 and 45 progeny per sire were genotyped with the three SNP-multiplexes. Linkage analyses on co-segregation of SNP alleles from sires with wool phenotypes of progeny were done across all the sires and within sire groups. Based on theoretical genome-wide threshold (F-value 10.13 and nominal P = 0.0016 for within-sire suggestive level), one familyshowed suggestive quantitative trait loci for greasy fleece weight on OAR1 and fibre diameter variability on OAR3. For these experimental animals, the results show no strong evidence of involvement of keratin and KRTAP genes in the wool characteristics analysed.
机译：进行连杆研究以检测可能影响羊毛特征的角蛋白和角蛋白相关蛋白（Krtap）的基因的变化。迄今为止，已经在绵羊中鉴定出这样的基因：其中85个（-91％）在三种染色体区域中聚集。将21个基因分组在绵羊染色体1（OAR1）的4-MBP区域内，在染色体3（OAR3）上的1-Mbp段中，36个在染色体11（OAR11）的1.3Mbp位点内聚集。 。在该工作中使用的DNA标记是分散在这些角蛋白和KRTAP基因簇的单核苷酸多态性（SNP）。标记设计为三个SNP多路复用：25-SNP，15-SNP和19-SNP多重用于OAR1，OAR3和OAR11上的角蛋白/ KRTAP区域。资源动物来自11个敌视家庭，其后代已经为油腻的羊毛重量，洗涤产率，纤维曲率和直径提供了表型。每胎的29至45个后代是用三种SNP多路复用的基因分型。在所有毛茸茸和胎儿组内完成了与羊毛表型的SNP等位基因共同分析的联系分析。基于理论基因组 - 宽阈值（F值10.13和标称P = 0.0016，用于急于暗示水平），在OAR1和OAR3上的桨卵石和纤维直径可变性的油腻羊毛重量的一个家庭显影性的定量性状基因座。对于这些实验动物，结果表明，在分析的羊毛特征中没有发现角蛋白和Krtap基因参与的强大证据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号