The aim of this study was to evaluate the protective effects of genistein on exercise-induced oxidative damage in mice. Male mice were randomly divided into four groups: a control or one of three genistein treated groups (7, 15, and 30 mg/kg). Genistein was orally administered to mice once a day for 4 weeks, while the control group received physiological saline. After 4 weeks, mice were required to run until exhaustion on the treadmill. Their Creatine Kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the serum, as well as superoxide dismutase (SOD), Glutathione Peroxidase (GPx) and malondialdehyde (MDA) in the muscle were determined. As a result, when compared to the control group, genistein supplementation decreased CK, LDH, AST, and ALT levels in the serum, as well as MDA levels in the muscle, and increased SOD and GPx levels in the muscle. The findings suggest that genistein has protective effects against exhaustive exercise-induced oxidative damage.
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