Hydrogen peroxide level in tumor cells during cisplatin-induced apoptosis

机译：顺铂诱导的细胞凋亡期间肿瘤细胞过氧化氢水平

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Using flow cytometry with a genetically encoded fluorescent sensor, vital dye and two types of apoptosis markers: PE Annexin V and TMRE, the participation of hydrogen peroxide (H_2O_2) in cisplatin-induced apoptosis was demonstrated. It was shown that cisplatin causes the increase of H_2O_2 level in early apoptotic cancer cells. Accumulation of H_2O_2 begins before the externalization of phosphatidylserine but after the loss of mitochondrial membrane potential. Scavenging of H_2O_2 prevents the cisplatin-induced apoptosis.

机译：使用流式细胞术与遗传编码的荧光传感器，重要染料和两种凋亡标志物：PE annexin V和TMRE，证明了过氧化铂诱导的细胞凋亡中的过氧化氢（H_2O_2）的参与。结果表明，顺铂导致早期凋亡癌细胞中的H_2O_2水平的增加。在磷脂酰丝氨酸的外化之前，H_2O_2的积累开始，但在线粒体膜电位损失之后。清除H_2O_2可防止顺铂诱导的细胞凋亡。

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《SPIE Conference on Medical Laser Applications and Laser-Tissue Interactions》|2019年|1 v. (various pagings) :|共3页
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Anastasiya S. Nerush; Kseniya M. Shchukina; Irina V. Balalaeva; Anna G. Orlova;
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中图分类 N-532;
关键词
hydrogen peroxide; genetically encoded sensor HyPer2; apoptosis; flow cytometry; cancer cell; N-acetil-L-cysteine; cisplatin;

机译：过氧化氢;遗传编码传感器Hyper2;细胞凋亡;流式细胞术;癌细胞;N-乙酰-1-半胱氨酸;顺铂;

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专利

1. Intracellular levels of hydrogen peroxide and nitric oxide in oocytes at various stages of meiotic cell cycle and apoptosis. [J] . Tripathi A, Khatun S, Pandey AN, Free radical research . 2009,第3期

机译：在减数分裂细胞周期和凋亡的各个阶段，卵母细胞的细胞内过氧化氢和一氧化氮水平。
2. Specific processing of poly (ADP-ribose) polymerase, accompanied by activation of caspase-3 and elevation/reduction of ceramide/hydrogen peroxide levels, during induction of apoptosis in host HL-60 cells infected by the human granulocytic ehrlichiosi [J] . Anna M.DiPietrantonio, Tze-Chen Hsieh, Joseph M.Wu IUBMB life . 2000,第1期

机译：聚（ADP-核糖）聚合酶的特异性加工，伴随caspase-3的活化和神经酰胺/过氧化氢水平的升高/降低，在人类粒细胞埃希氏菌感染的宿主HL-60细胞的凋亡诱导中
3. Depletion of OLFM4 gene inhibits cell growth and increases sensitization to hydrogen peroxide and tumor necrosis factor-alpha induced-apoptosis in gastric cancer cells [J] . Rui-hua Liu, Mei-hua Yang, Hua Xiang, Journal of biomedical science. . 2012,第1期

机译：OLFM4基因的耗竭抑制细胞生长并增加对胃癌细胞中过氧化氢和肿瘤坏死因子-α诱导的细胞凋亡的敏感性
4. Hydrogen peroxide level in tumor cells during cisplatin-induced apoptosis [C] . Anastasiya S. Nerush, Kseniya M. Shchukina, Irina V. Balalaeva, SPIE Conference on Medical Laser Applications and Laser-Tissue Interactions . 2019

机译：顺铂诱导的细胞凋亡期间肿瘤细胞过氧化氢水平
5. Effects of hemorrhagic shock and fraction of inspired oxygen on hydrogen peroxide and apoptosis in rat lung and diaphragm. [D] . Mach, William J. 2010

机译：失血性休克和吸入氧气的分数对大鼠肺和diaphragm肌中过氧化氢和细胞凋亡的影响。
6. Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide isan effector mechanism for drug-induced apoptosis in tumor cells. [O] . Jayshree L. Hirpara, Marie-Véronique Clément, Shazib Pervaiz 2014

机译：线粒体来源的过氧化氢引发的细胞内酸化是药物诱导肿瘤细胞凋亡的效应机制。
7. Depletion of OLFM4 gene inhibits cell growth and increases sensitization to hydrogen peroxide and tumor necrosis factor-alpha induced-apoptosis in gastric cancer cells [O] . Rui-hua Liu, Mei-hua Yang, Hua Xiang, 2012

机译：OLFM4基因的耗竭抑制细胞生长并增加对胃癌细胞中过氧化氢和肿瘤坏死因子-α诱导的细胞凋亡的敏感性

Hydrogen peroxide level in tumor cells during cisplatin-induced apoptosis

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