A Molecular Dynamic Study of Layered Hydroxide Induced Depletion of Mobile Anions within the Extracellular Medium

机译：层状氢氧化物诱导细胞外培养基移动阴离子耗尽的分子动态研究

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The strong surface electric charge density of clay mineral host nanolayers enables their use as host-guest nanohybrids in many different areas of application. In particular, layered double hydroxides (LDH) of metals have found applications in medicine. Drug-LDH or gene-LDH nanohybrids are used for targeted delivery of biomedical agents to diseased cells or cancer cells. Fragments of the LDH host nanolayers may remain both within the cell and in the extracellular medium after drug delivery. How these charged nanosheets affect the cell electrostatics is still poorly understood. In the present paper, the idealized case of a single pure Mg_2/Al-LDH nanolayer interacting with the extracellular anion environment was investigated to estimate the order of magnitude of a possible shift of the cell membrane equilibrium potential. An approximate dependence of the change in the chloride equilibrium membrane potential on the concentration of pure Mg_2/Al-LDH nanosheets was determined.

机译：粘土矿物宿主纳米组的强表面电荷密度使其在许多不同应用领域中使用它们作为宿主的纳米冬青。特别地，金属的层状双氢氧化物（LDH）已发现医学中的应用。药物-LDH或基因-LDH纳米冬冬胺用于靶向递送生物医药剂或患病细胞或癌细胞。在药物递送后，LDH宿主纳米组的片段可以保持在细胞内和细胞外培养基中。这些带电的纳米表如何影响细胞静电仍然明白。在本文中，研究了与细胞外阴离子环境相互作用的单个纯Mg_2 / Al-LDH纳米层的理想情况下，以估计细胞膜平衡电位的可能偏移的幅度。测定了氯化物平衡膜电位对纯Mg_2 / Al-LDH纳米浓度浓度的近似依赖性。

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《Internation Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures》|2015年||共4页
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Alexey A. Tsukanov; Sergey G. Psakhie;
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中图分类 TB3-532;
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layered double hydroxide; membrane potential; anion capturing; ion transport; molecular dynamics;

机译：分层双氢氧化物;膜势;阴离子捕获;离子运输;分子动力学;

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1. Molecular dynamics modeling of the structures and binding energies of alpha-nickel hydroxides and nickel-aluminum layered double hydroxides containing various interlayer guest anions [J] . Li H, Ma J, Evans DG, Chemistry of Materials: A Publication of the American Chemistry Society . 2006,第18期

机译：包含各种层间客体阴离子的α-镍氢氧化物和镍铝层状双氢氧化物的结构和结合能的分子动力学建模
2. Molecular dynamics modeling of the structures and binding energies of alpha-nickel hydroxides and nickel-aluminum layered double hydroxides containing various interlayer guest anions [J] . Li H, Ma J, Evans DG, Chemistry of Materials: A Publication of the American Chemistry Society . 2006,第18期

机译：包含各种层间客体阴离子的α-镍氢氧化物和镍铝层状双氢氧化物的结构和结合能的分子动力学建模
3. Anion exchange behavior of (MAl)-Al-II layered double hydroxides: a molecular dynamics and DFT study [J] . Zhao Xiao-Jie, Zhu Yu-Quan, Xu Si-Min, Physical chemistry chemical physics: PCCP . 2020,第35期

机译：（MAL）-A1层分层双氢氧化物的阴离子交换行为：分子动力学和DFT研究
4. A Molecular Dynamic Study of Layered Hydroxide Induced Depletion of Mobile Anions within the Extracellular Medium [C] . Alexey A. Tsukanov, Sergey G. Psakhie Internation Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures . 2015

机译：层状氢氧化物诱导细胞外培养基移动阴离子耗尽的分子动态研究
5. Part I. Layered double hydroxides (LDHs): Organic anion exchange reactions, synthesis of microporous pillared derivatives and surface chemistry of metal carbonyl clusters. Part II. On the nature of titania pillared layered silicate clays. [D] . Dimotakis, Emmanuel Dimitrios. 1991

机译：第一部分：层状双氢氧化物（LDHs）：有机阴离子交换反应，微孔柱状衍生物的合成和羰基金属簇的表面化学。第二部分在二氧化钛的性质上有柱状层状硅酸盐粘土。
6. Energy and structure of bonds in the interaction of organic anions with layered double hydroxide nanosheets: A molecular dynamics study [O] . A.A. Tsukanov, S.G. Psakhie -1

机译：有机阴离子与层状双氢氧化物纳米片相互作用中的键的能量和结构：分子动力学研究
7. Molecular Dynamics Modeling of the Structures and Binding Energies of a-Nickel Hydroxides and Nickel-Aluminum Layered Double Hydroxides Containing Various Interlayer Guest Anions [O] . -1

机译：含镍氢氧化物和镍铝层叠双氢氧化物的结构和结合能量的分子动力学建模，含有各种层间阴离子的镍 - 铝层

A Molecular Dynamic Study of Layered Hydroxide Induced Depletion of Mobile Anions within the Extracellular Medium

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