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Clarification of the irritating and toxic effects of bentonite-like clays

机译：澄清膨润土状粘土的刺激性和毒性作用

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This article studies the action and biocompatibility of the developed montmorillonite-containing preparation "Sorbent" on experimental animals with its long-term use. The local irritating effect of the "Sorbent" preparation was evaluated by its effect on the gastric mucosa of animals with experimental ulcerative pathology. The size of the most common particles in the suspension is 5-8 microns. The experiments were carried out on white rats of the Wistar line and non-linear Hartley guinea pigs. To identify the irritating effect, the drug was administered to animals in therapeutic doses of 200 mg/kg and three times the conditionally therapeutic dose - 600 mg/kg of body weight. Destructive changes in the stomachs of experimental animals were studied macroscopically. The ulcerogenic effect was evaluated by calculating the Pauls index.
机译：本文研究了含有Montmorililonite的制备“吸附剂”在实验动物上的作用和生物相容性，其长期使用。 “吸附剂”制剂的局部刺激作用是通过其对具有实验性溃疡性病理学的动物胃粘膜的影响来评价。 悬浮液中最常见的颗粒的尺寸为5-8微米。 实验在Wistar线和非线性Hartley豚鼠的白鼠上进行。 为了鉴定刺激性效果，将该药物施用于200mg / kg的治疗剂量的动物，并且有条件治疗剂量的三倍，体重为600mg / kg体重。 研究了实验动物胃的破坏性变化。宏观研究了实验动物的胃。 通过计算Pauls指数来评估溃疡性效果。

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