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Synthesis and conformational study of(Bin)n and(beta 2,2-Bin)n homopeptides based on atropoisomeric alpha-and beta-amino acids derived from 1,1'-binaphthyl

机译：基于阿托异构体α-β-氨基酸的（Bin）N和（β2,2-Zin）N和（Beta 2,2-Zin）N和（β2,2-Zin）N蛋白肽的合成和构象研究衍生自1,1'-二氯基苯

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The exploitation of C~(alpha,alpha)-disubstituted glycines with well-defined stereochemical properties have greatly enhanced the scope of peptide design by imposing local restrictions on backbone conformation.Oligomers of beta-amino acids have also emerged in the past few years as capable of forming highly stable secondary structures.In this connection,inter alia we have previously shown that Bin,a novel C~(alpha,alpha)-disubstituted glycine possessing only an axial chirality,behaves as a 3_(10)-helix inducer and can give rise to efficient rigid helical peptide fluorophores.Here,we present our results on the synthesis and a conformational study of homo-a-peptides based on(S)-Bin as well as of linear and cyclic homo-P-peptides based on(R)-beta~(2,2)-Bin(Fig.1),using FT-IR absorption,NMR and CD techniques.

机译：C〜（α，α） - 具有明确定义的立体化学性质的甘氨酸的开发，通过施加局部限制对骨干构象的局部限制极大地增强了肽设计的范围。过去几年也出现了β-氨基酸的oligomers。能够形成高度稳定的二次结构。在这种连接中，除其他外，我们之前已经表明，只有仅具有轴向手性的新型C〜（α，α） - 替代甘氨酸，表现为3_（10）-helix诱导剂和可以产生高效的刚性螺旋肽荧光团。我们介绍了基于（S）-Bin以及基于线性和环状同源p-肽的合成和均型肽的合成和构象研究的结果。（r）-beta〜（2,2）-bin（图1），使用FT-IR吸收，NMR和CD技术。

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《International Peptide Symposium;European Peptide Symposium》|2005年||共2页
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Anne Gaucher; Laurence Dutot; Karen Wright;
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1. A Widely Applicable Method of Resolution of Binaphthyls: Preparation of Enantiomerically Pure 1,1'- Bin aphthalene-2,2'-diol, 1,1'-Binaphthalene-2,2'-dithiol, 2'-Mercapto-1,1 '-binaphthalen-2-ol, and 1,1'-Binaphthalene-8,8'-diol [J] . Davide Fabbri, Giovanna Delogu, Ottorino De Lucchi The Journal of Organic Chemistry . 1995,第20期

机译：解析双萘基的广泛应用的方法：对映体纯的1,1'- Bin萘-2,2'-二醇，1,1'-Binaphthalene-2,2'-二硫醇，2'-Mercapto-1,1的制备'-联萘-2-醇和1,1'-联萘-8,8'-二醇
2. Synthesis and conformational study of homo-peptides based on (S)-Bin, a C-2-symmetric binaphthyl-derived C-alpha,C-alpha-disubstituted glycine with only axial chirality [J] . Mazaleyrat JP., Wright K., Gaucher A., Tetrahedron, Asymmetry: The International Journal for Repid Publication on all Aspects of Asymmetry in Orgainc, Inorganic, Organometallic, Physical and Bio-Organic Chemistry . 2003,第13期

机译：基于（S）-Bin的同肽的合成和构象研究，S-Bin是仅具有轴向手性的C-2-对称双萘基衍生的C-alpha，C-alpha-二取代甘氨酸
3. A NEW CHIRAL ALPHA-AMINOACID WITH ONLY AXIAL DISSYMMETRY - SYNTHESIS AND X-RAY ANALYSIS OF A 1,1'-BINAPHTHYL-SUBSTITUTED ALPHA-AMINOISOBUTYRIC ACID (BIN) AND OF ITS BIPHENYL ANALOGUE (BIP) [J] . Mazaleyrat JP., Wakselman M., Tchertanov L., Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 1996,第17期

机译：一种新型的仅具有轴对称性的手性α-酰胺酸-1,1'-联萘取代的α-酰胺异丁酸（BIN）及其联苯酚类似物（BIP）的合成和X射线分析
4. Synthesis and conformational study of(Bin)n and(beta 2,2-Bin)n homopeptides based on atropoisomeric alpha-and beta-amino acids derived from 1,1'-binaphthyl [C] . Anne Gaucher, Laurence Dutot, Karen Wright International Peptide Symposium;European Peptide Symposium . 2005

机译：基于阿托异构体α-β-氨基酸的（Bin）N和（β2,2-Zin）N和（Beta 2,2-Zin）N和（β2,2-Zin）N蛋白肽的合成和构象研究衍生自1,1'-二氯基苯
5. Constrained beta-prolines. (I) Methanopyrrolidine beta-amino acids: Synthesis and chracterization of novel C6-substituted analogues and peptide oligomers. (II) Synthesis of 2,2-disubstituted pyrrolidine-3-carboxylic acids. [D] . Hu, Zilun. 2015

机译：受约束的β-脯氨酸。（I）甲基吡咯烷β-氨基酸：新型C6取代的类似物和肽低聚物的合成和表征。（II）2，2-二取代的吡咯烷-3-羧酸的合成。
6. Transaminases for the synthesis of enantiopure beta-amino acids [O] . Jens Rudat, Birgit R Brucher, Christoph Syldatk 2012

机译：转氨酶用于合成对映纯的β-氨基酸
7. Synthesis of the spin-labelled beta-amino acids cis- and trans-beta-TOAC, and conformational study of a trans-beta-TOAC/ACHC hexapeptide [O] . WRIGHT K, SARCIAUX M, WAKSELMAN M, 2005

机译：自旋标记的β-氨基酸的顺式和反式-TOAC的合成，以及反式-TOAC / ACHC六肽的构象研究
8. Picosecond Dynamics of Barrier Crossing in Solution: A Study of the Conformational Change of Excited State 1,1'-Binaphthyl [R] . Eisenthal, K. B., Millar, D. P. 1985

机译：溶液中势垒穿越的皮秒动力学：激发态1,1'-联萘的构象变化研究

Synthesis and conformational study of(Bin)n and(beta 2,2-Bin)n homopeptides based on atropoisomeric alpha-and beta-amino acids derived from 1,1'-binaphthyl

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