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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Breastfeeding as a Predictor of Serum Concentrations of Per- and Polyfluorinated Alkyl Substances in Reproductive-Aged Women and Young Children: A Rapid Systematic Review
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Breastfeeding as a Predictor of Serum Concentrations of Per- and Polyfluorinated Alkyl Substances in Reproductive-Aged Women and Young Children: A Rapid Systematic Review

机译：母乳喂养作为血清血清浓度的血清浓度和多氟化烷基物质中的血清浓度（幼儿）和幼儿中的血清浓度：快速系统审查

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Background: Per- and polyfluorinated alkyl substances (PFASs) are ubiquitous, synthetic chemicals widely detected in human serum and breast milk. Objective: We conducted a rapid systematic review to assess the association between breastfeeding practices and serum concentrations of PFASs among reproductive-aged women and young children. Methods: We searched PubMed and Scopus for human studies that measured breastfeeding behavior and evaluated their associations with serum PFASs concentrations in women and children. We evaluated each study for the risk of bias (internal validity), and assessed the overall quality and strength of the evidence following the Navigation Guide systematic review approach. Results: We identified 14 relevant studies. Longer breastfeeding duration was significantly associated with increased serum concentrations of PFASs among infants/toddlers. Previous breastfeeding duration was significantly associated with lower serum concentrations of PFASs in pregnant and/or postnatal women. Specifically, children had 1-3% lower serum perfluorooctanoic acid (PFOA) concentrations and women had 4.7-6.0% higher serum PFOA concentrations, per month of breastfeeding. The overall risk of bias was rated as "probably low risk," and the body of evidence was rated as "high" and "moderate" quality for studies that assessed women and children, respectively. Conclusion: We conclude there is "sufficient" evidence supporting an association between breastfeeding and serum PFASs concentrations among women, but "limited" evidence of an association among children due to limited sample size and potential bias from confounding and exposure misclassification. These findings reinforce that lactation is an important excretion route of PFASs for women, and that breast milk may be an important exposure pathway for young children. Future studies should further investigate the implications of our findings for maternal and child health.
机译：背景：在人血清和母乳中广泛检测到普遍存存的烷基物质（PFASS）（PFASS）是普遍存存的，合成化学品。目的：我们进行了快速的系统审查，以评估生殖老年妇女和幼儿中母乳喂养习俗和血清浓度之间的关联。方法：我们搜索了PubMed和Scopus的人类研究，以测量母乳喂养行为，并评估其与血清PFASS浓度的妇女和儿童的关联。我们评估了对偏见的风险（内部有效性）的每一项研究，并评估了导航指南系统审查方法后的证据的整体质量和实力。结果：我们确定了14项相关研究。较长的母乳喂养持续时间与婴儿/小孩之间的血清浓度增加显着相关。以前的母乳喂养持续时间与孕妇和/或产后女性中血清血清浓度降低有显着相关。具体而言，每月母乳喂养，儿童血清全氟辛酸（PFOA）浓度浓度为1-3％的血清全氟辛酸（PFOA）浓度。偏见的总体风险被评为“可能是低风险”，并且证据体系被评为评为评估妇女和儿童的“高”和“中等”质量。结论：我们得出结论，支持女性中母乳喂养和血清金银粉浓度之间的关联的“足够”的证据，但由于样本量有限和潜在偏差，儿童的关联的“有限”证据来自混淆和暴露错误分类。这些发现强化了哺乳期是女性缺口的重要排泄途径，母乳可能是幼儿的重要曝光途径。未来的研究应该进一步调查我们对妇幼保健的影响的影响。

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