• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>International Conference of Chinese Society of Micro-Nano Technology;Annual Conference of the Chinese Society of Micro-Nano Technology >Design, fabrication and characterization of in-plane titanium microneedles for transdermal drug delivery
【24h】

Design, fabrication and characterization of in-plane titanium microneedles for transdermal drug delivery

机译：用于经皮给药的平面钛微针的设计，制造和表征

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this paper, in-plane titanium microneedles were developed combining laser micromachining and surface polishing. Compared with UV Laser, Picosecond Laser can produce smallest feature size with high aspect ratio. Appropriate acid polishing can not only clean off the debris, but also sharpen the edges of microneedle. Skin test reveals a cumulative permeation over 10,000 times larger than the untreated rat epidermal. And besides, the microneedles can endure hundreds of inserting routes. The in-plane titanium microneedles can be used with transdermal patches for drug delivery. And they can also be coated with drugs to enhance transdermal transport as well. By combining the MEMS process, traditional machine work with laser technology, various novel microneedles for transdermal drug delivery can be developed in the future.
机译：本文研究了结合激光微加工和表面抛光的平面钛微针。与紫外线激光相比，皮秒激光可以产生最小的特征尺寸，并具有高纵横比。适当的酸抛光不仅可以清除碎屑，还可以使微针的边缘变锋利。皮肤测试显示，累积渗透率比未经处理的大鼠表皮高出10,000倍。此外，微针还可以承受数百条插入路径。平面钛微针可与透皮贴剂一起用于药物递送。它们也可以涂上药物以增强透皮运输。通过将MEMS工艺，传统机器与激光技术相结合，将来可以开发出各种用于透皮给药的新型微针。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号