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Injection Molded Microfluidic Devices for Biological Sample Separation and Detection

机译：用于生物样品分离和检测的注射成型微流控设备

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摘要

We are developing a variety of microsystems for the separation and detection of biological samples. At the heart of these systems, inexpensive polymer microfluidic chips carry out sample preparation and analysis. Fabrication of polymer microfluidic chips involves the creation of a master in etched silicon or glass; plating of the master to produce a nickel stamp; large lot chip replication by injection molding; precision chip sealing; and chemical modification of channel surfaces. Separation chips rely on insulator-based dielectrophoresis for the separation of biological particles. Detection chips carry out capillary electrophoresis to detect fluorescent tags that identify specific biological samples. Since the performance and reliability of these microfluidic chips are very sensitive to fluidic impedance, electromagnetic flux, and zeta potential, the microchannel dimensions, shape, and surface chemistry have to be tightly controlled during chip fabrication and use. This paper will present an overview of chip design, fabrication, and testing. Dimensional metrology data, surface chemistry characterization, and chip performance data will be discussed in detail.
机译：我们正在开发各种用于分离和检测生物样品的微系统。这些系统的核心是廉价的聚合物微流控芯片，用于样品制备和分析。聚合物微流控芯片的制造涉及在蚀刻的硅或玻璃中创建母版。电镀母版以产生镍印章；通过注射成型大量复制芯片；精密切屑密封；通道表面的化学修饰。分离芯片依靠基于绝缘体的介电泳来分离生物颗粒。检测芯片进行毛细管电泳以检测识别特定生物样品的荧光标签。由于这些微流体芯片的性能和可靠性对流体阻抗，电磁通量和Zeta电位非常敏感，因此在芯片制造和使用过程中必须严格控制微通道的尺寸，形状和表面化学性质。本文将概述芯片设计，制造和测试。尺寸计量数据，表面化学特征和芯片性能数据将详细讨论。

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