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首页> 外文会议>Conference on Micromachining and Microfabrication Process Technology >Injection Molded Microfluidic Devices for Biological Sample Separation and Detection
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Injection Molded Microfluidic Devices for Biological Sample Separation and Detection

机译：用于生物样品分离和检测的注塑微流体装置

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摘要

We are developing a variety of microsystems for the separation and detection of biological samples. At the heart of these systems, inexpensive polymer microfluidic chips carry out sample preparation and analysis. Fabrication of polymer microfluidic chips involves the creation of a master in etched silicon or glass; plating of the master to produce a nickel stamp; large lot chip replication by injection molding; precision chip sealing; and chemical modification of channel surfaces. Separation chips rely on insulator-based dielectrophoresis for the separation of biological particles. Detection chips carry out capillary electrophoresis to detect fluorescent tags that identify specific biological samples. Since the performance and reliability of these microfluidic chips are very sensitive to fluidic impedance, electromagnetic flux, and zeta potential, the microchannel dimensions, shape, and surface chemistry have to be tightly controlled during chip fabrication and use. This paper will present an overview of chip design, fabrication, and testing. Dimensional metrology data, surface chemistry characterization, and chip performance data will be discussed in detail.
机译：我们正在开发各种微系统，用于分离和检测生物样品。在这些系统的心脏，廉价的聚合物微流体芯片进行样品制备和分析。聚合物微流体芯片的制备涉及在蚀刻硅或玻璃中的施主的产生;大师的镀层生产镍戳;注塑成型的大量芯片复制;精密芯片密封;和沟道表面的化学改性。分离芯片依赖于基于绝缘体的介电电泳进行生物颗粒的分离。检测芯片对毛细管电泳进行毛细管电泳检测识别特定生物样品的荧光标签。由于这些微流体芯片的性能和可靠性对流体阻抗，电磁通量和Zeta电位非常敏感，因此在芯片制造和使用期间必须紧密地控制微通道尺寸，形状和表面化学。本文将概述芯片设计，制造和测试。尺寸计量数据，表面化学表征和芯片性能数据将详细讨论。

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