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首页> 外文会议>Nanotechnology amp; applications >SAFE WORK WITH NANOPARTICLES THROUGH AN OCCUPATIONAL RISK MANAGEMENT APPROACH AND A PREVENTION PROGRAM
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SAFE WORK WITH NANOPARTICLES THROUGH AN OCCUPATIONAL RISK MANAGEMENT APPROACH AND A PREVENTION PROGRAM

机译：通过职业风险管理方法和预防计划，使用纳米颗粒进行安全工作

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摘要

Engineered nanoparticles (NPs) are developed in research laboratories and produced in industrial plants, where the most extensive exposures are likely to occur. Many toxicological studies have demonstrated various specific health risks related to the absorption of NPs but data are still limited and numerous uncertainties remain. On a mass basis, NPs are normally more toxic than the same substances in larger dimensions. These particles show size-dependent adverse biological effects, and occupational exposure must be maintained as low as possible. Our visits to occupational settings demonstrate that many workers are not aware of the potential risks and, in many situations, do not implement appropriate procedures to limit occupational exposure to these products. This article proposes a framework for occupational risk management with the objective of controlling exposure to NPs in a context of a major lack of specific data related to the toxicity of these substances and to the level of occupational exposure. The framework focuses on a structured approach dealing with hazard identification, exposure characterization, risk assessment and risk management. These are included in a prevention program that must be followed up, once it has been implemented, and refined through an iterative approach as new data become available.
机译：工程纳米颗粒（NPs）在研究实验室开发，并在可能发生最广泛暴露的工业工厂中生产。许多毒理学研究表明与NP吸收有关的各种特定的健康风险，但数据仍然有限，仍然存在许多不确定性。以质量为基准，NPs在更大尺寸上通常比相同物质有更大的毒性。这些颗粒显示出与尺寸有关的不利生物学效应，因此必须将职业接触保持在尽可能低的水平。我们对职业环境的访问表明，许多工人没有意识到潜在的风险，并且在许多情况下，没有实施适当的程序来限制职业对这些产品的接触。本文提出了一个职业风险管理框架，其目的是在与这些物质的毒性和职业暴露水平有关的具体数据严重缺乏的情况下，控制对NP的暴露。该框架着重于处理危害识别，暴露特征，风险评估和风险管理的结构化方法。这些都包含在预防计划中，一旦实施，就必须跟进，并在获得新数据时通过迭代方法进行完善。

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