首页> 外文会议>NATO Advanced Study Institute on Polymer Based Systems on Tissue Engineering, Replacement and Regeneration Oct 15-25, 2001 Alvor, Algarve, Portugal >CHARACTERIZATION OF DEGRADABLE POLYMERS FOR ORTHOPEDIC APPLICATION Examining Tyrosine-Derived Polycarbonates for Tissue Engineering of Bone
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CHARACTERIZATION OF DEGRADABLE POLYMERS FOR ORTHOPEDIC APPLICATION Examining Tyrosine-Derived Polycarbonates for Tissue Engineering of Bone

机译:骨科应用中可降解聚合物的表征研究酪氨酸衍生的聚碳酸酯在骨组织工程中的应用

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摘要

As tissue engineering conies to the forefront as a cutting-edge discipline, one of the principle challenges is the need for new materials that are fully bioresorbable and biocompatible. To this extent, pseudo-poly(amino acid)s such as tyrosine-derived polycarbonates present themselves as a promising new class of degradable polymers. These materials offer a high degree of bone biocompatibility. Varations in pendent chain structure allow the generation of a series of materials with variations in key mechanical and cellular response properties. In addition, their chemical structure provides convenient attachment points for the covalent linkage of bioactive molecules to the polymer backbone. Tyrosine-derived polycarbonates can be shaped by commonly used processing and fabrication methods - another advantage over conventional poly(amino acid)s which are often non-processible.
机译:随着组织工程学作为最前沿的学科走到最前沿,主要的挑战之一是需要完全可生物吸收和生物相容的新材料。在此程度上,假聚(氨基酸),例如酪氨酸衍生的聚碳酸酯,将自己呈现为有希望的新型可降解聚合物。这些材料具有高度的骨骼生物相容性。侧链结构的变化允许生成一系列材料,这些材料在关键的机械和细胞响应特性方面都有变化。此外,它们的化学结构为生物活性分子与聚合物主链的共价连接提供了方便的连接点。酪氨酸衍生的聚碳酸酯可以通过常用的加工和制造方法进行成型,这是与通常无法加工的常规聚氨基酸相比的另一个优势。

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