• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>NMR spectroscopy of polymers: Innovative strategies for complex macromolecules >The Interaction of Aβ(1-40) Peptide with Lipid Bilayers and Ganglioside As Studied by Multinuclear Solid-State NMR
【24h】

The Interaction of Aβ(1-40) Peptide with Lipid Bilayers and Ganglioside As Studied by Multinuclear Solid-State NMR

机译：多核固态NMR研究Aβ（1-40）肽与脂质双层和神经节苷脂的相互作用

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Amyloid β-peptide (Aβ) is a major component of plaques in Alzheimer's disease, and formation of senile plaques has been suggested to originate from regions of neuronal membrane rich in gangliosides. We have analyzed the interaction of Aβ with lipid bilayers by multinuclear NMR using ~(15)N, ~(31)P and ~(13)C nuclei. The result of the present study implies that the fibrillogenic seed nucleus involves an interaction of His residues with the sialic acid moiety of GM1. Moreover, Aβ(1-40) with ganglioside GM1 perturbs the bilayer structure to form a non-lamellar structure such as hexagonal H_(11) lipids and also produces single vesicles or micelles, as shown by angular-dependent ~(31)P NMR experiments. In conclusion, the Aβ peptide penetrates into the lipid bilayer, takes on an α-helical form, and produces non-lamellar lipid and micelles.
机译：淀粉样蛋白β肽（Aβ）是阿尔茨海默氏病中斑块的主要成分，并且已提出老年斑的形成源自富含神经节苷脂的神经元膜区域。我们已经使用〜（15）N，〜（31）P和〜（13）C核通过多核NMR分析了Aβ与脂质双层的相互作用。本研究的结果暗示原纤维形成的种子核涉及His残基与GM1的唾液酸部分的相互作用。此外，具有神经节苷脂GM1的Aβ（1-40）会扰乱双层结构以形成非层状结构（例如六角形H_（11）脂质），并且还会产生单个囊泡或胶束，如角度依赖性〜（31）P NMR所示。实验。总之，Aβ肽渗透到脂质双层中，呈α-螺旋形式，并产生非片状脂质和胶束。

著录项

  • 来源
  • 会议地点 Honolulu HI(US);Honolulu HI(US)
  • 作者

    Yasumoto Nakazawa; Yu Suzuki; Hazime Saito; Tetsuo Asakura;

  • 作者单位

    Institute of Engineering, Tokyo University of Agriculture and Technology,2-24-16, Nakacho, Koganei, Tokyo, 184-8588 Japan;

    Institute of Engineering, Tokyo University of Agriculture and Technology,2-24-16, Nakacho, Koganei, Tokyo, 184-8588 Japan;

    Department of Life Science, Himeji Institute of Technology,University of Hvogo, Kamigori, Hvoeo, 678-1297 Japan;

    Institute of Engineering, Tokyo University of Agriculture and Technology,2-24-16, Nakacho, Koganei, Tokyo, 184-8588 Japan;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 聚合反应过程;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号