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首页> 外文会议>Optical Coherence tomography and coherence domain optical methods in biomedicine XIX >One-micron resolution optical coherence tomography (OCT) in vivo for cellular level imaging
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One-micron resolution optical coherence tomography (OCT) in vivo for cellular level imaging

机译：用于细胞水平成像的体内一微米分辨率光学相干断层扫描（OCT）

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摘要

We developed a spectral domain OCT system combining two NIR, CW light sources of different spectral range. Its resolving power is validated by visualizing the cellular structures of zebra fish larvae in vivo. An NIR extended illumination from 755-1100 nm is achieved. The axial resolution is 1.27 μm in air, corresponding to 0.93 μm in tissue (n=1.36), which is the highest axial resolution using NIR, CW laser sources up to date to the best of our knowledge. In vivo imaging is conducted to demonstrate the resolving power of proposed one-micron resolution OCT system. The top and bottom surfaces of individual disk-like red blood cell is reliably visualized, as well as flat, spindle shaped endothelial cells lining along the luminal surface of the blood vessel wall. This study provides a viable solution for cellular and subcellular level OCT imaging system which is also very competitive in cost.
机译：我们开发了一种光谱域OCT系统，该系统结合了两个不同光谱范围的NIR，CW光源。通过可视化体内斑马鱼幼虫的细胞结构来验证其分辨力。实现了从755-1100 nm的近红外扩展照明。空气中的轴向分辨率为1.27μm，相当于组织中的轴向分辨率为0.93μm（n = 1.36），这是使用我们所知最新的近红外，连续波激光光源的最高轴向分辨率。进行体内成像以证明所提出的一微米分辨率OCT系统的分辨能力。可以可靠地看到单个盘状红细胞的顶面和底面，以及沿血管壁腔表面排列的扁平纺锤状内皮细胞。这项研究为细胞和亚细胞水平的OCT成像系统提供了可行的解决方案，其成本也极具竞争力。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Dongyao Cui; Xinyu Liu; Jing Zhang; Xiaojun Yu; Sun Ding; Yuemei Luo; Jun Gu; Ping Shum; Linbo Liu;

  • 作者单位

    School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798,COFT, The Photonics Institute (TPI), Nanyang Technological University, Singapore 639798,CINTRA CNRS/NTU/THALES, UMI3288, Singapore 637553;

    School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798;

    School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798;

    School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798;

    School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798;

    School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798;

    School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798;

    School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798,COFT, The Photonics Institute (TPI), Nanyang Technological University, Singapore 639798,CINTRA CNRS/NTU/THALES, UMI3288, Singapore 637553;

    School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798,School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459,COFT, The Photonics Institute (TPI), Nanyang Technological University, Singapore 639798;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Optical Coherence Tomography (OCT); resolution; in vivo;

    机译：光学相干断层扫描（OCT）；解析度;体内;

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