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Depth encoded three-beam swept source Doppler optical coherence tomography

机译:深度编码三束扫频源多普勒光学相干断层扫描

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摘要

A novel approach for investigation of human retinal and choroidal blood flow by the means of multi-channel swept source Doppler optical coherence tomography (SS-D-OCT) system is being developed. We present preliminary in vitro measurement results for quantification of the 3D velocity vector of scatterers in a flow phantom. The absolute flow velocity of moving scatterers can be obtained without prior knowledge of flow orientation. In contrast to previous spectral domain (SD-) D-OCT investigations, that already proved the three-channel D-OCT approach to be suitable for in vivo retinal blood flow evaluation, this current work aims for a similar functional approach by means of a differing technique. To the best of our knowledge, this is the first three-channel D-OCT setup featuring a wavelength tunable laser source. Furthermore, we present a modification of our setup allowing a reduction of the former three active illumination channels to one active illumination channel and two passive channels, which only probe the illuminated sample. This joint aperture (JA) approach provides the advantage of not having to divide beam power among three beams to meet corresponding laser safety limits. The in vitro measurement results regarding the flow phantom show good agreement between theoretically calculated and experimentally obtained flow velocity values.
机译:正在开发一种通过多通道扫频源多普勒光学相干断层扫描(SS-D-OCT)系统研究人类视网膜和脉络膜血流的新方法。我们提出了初步的体外测量结果,用于量化流幻影中散射体的3D速度矢量。无需事先了解流向即可获得移动散射体的绝对流速。与先前的光谱域(SD-)D-OCT研究相反,该研究已经证明三通道D-OCT方法适用于体内视网膜血流评估,该当前工作旨在通过一种类似的功能方法不同的技术。据我们所知,这是第一个具有波长可调激光源的三通道D-OCT装置。此外,我们对设置进行了修改,允许将以前的三个主动照明通道减少为一个主动照明通道和两个被动通道,这两个通道仅探测被照明的样本。这种联合孔径(JA)方法具有不必在三个光束之间分配光束功率即可满足相应的激光安全限制的优点。关于体模的体外测量结果表明,理论计算值和实验获得的流速值之间具有良好的一致性。

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