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Digital image processing for the early localization of cancer

机译:用于癌症早期定位的数字图像处理

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Abstract: The prognosis for cancer patients becomes much better if a tumor is diagnosed, localized and treated early, in a precancerous stage. The difficulty lies in the localization of cancerous tumors. Carcinoma in situ (CIS) refers to a tumor which is approximately 100 microns thick and one which has not penetrated through the epithelium wall or become invasive (2). A tumor of this size cannot be detected by existing techniques such as x-ray, computer tomography, magnetic resonance imaging, nuclear medicine or conventional endoscopy under white-light illumination. However, these tumors can be localized and destroyed by photodynamic diagnosis and therapy. This research shows that digital image processing and the technique of digital image ratioing contribute to photodynamic diagnosis and the early localization of cancer. A software package has been developed as a result of this research. The software package quantifies the usefulness of digital image processing for tumor localization and detectability. System parameters such as the endoscope distance and angle variations, tumor size and tumor concentration, sensitivity and specificity of the system have been tested and quantified.!
机译:摘要:如果在癌前期及早诊断,定位和治疗肿瘤,则癌症患者的预后会好得多。困难在于癌性肿瘤的定位。原位癌(CIS)是指一种大约100微米厚的肿瘤,尚未穿透上皮壁或浸润(2)。这种大小的肿瘤无法通过现有技术(例如X射线,计算机断层扫描,磁共振成像,核医学或常规内窥镜在白光照射下)进行检测。但是,这些肿瘤可以通过光动力诊断和治疗来定位和破坏。这项研究表明,数字图像处理和数字图像配比技术有助于光动力诊断和癌症的早期定位。这项研究的结果是开发了一个软件包。该软件包量化了数字图像处理对肿瘤定位和可检测性的有用性。系统参数,例如内窥镜距离和角度变化,肿瘤大小和肿瘤浓度,系统的敏感性和特异性,已经过测试和量化。

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