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首页> 外文会议>Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques >Fluorescence detection of tumors: studies on the early diagnosis of microscopic lesions in preclinical and clinical studies
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Fluorescence detection of tumors: studies on the early diagnosis of microscopic lesions in preclinical and clinical studies

机译：肿瘤的荧光检测：临床前和临床研究中微观病变的早期诊断研究

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Abstract: The growth of microscopic tumor lesions at or beyond treatment field lesions poses major problems in the diagnosis and curative treatment of numerous cancers. Early detection techniques which clearly define the extent of condemned or field spread of disease may improve the primary treatment of the disease. In vivo fluorescence photometry is a non-imaging technique which digitally displays relative fluorescence values in volts. The sensitivity of the instrument has allowed the detection of micrometastases in both pre-clinical and clinical studies using drug doses that are 80-90% lower than those used therapeutically. This technique is now being applied in preliminary experiments to the hamster cheek pouch models to (1) discern varying grades of dysplasia; (2) levels of uptake of the drug in normal growing and quiescent tumors. Results will be shown in two models in which this technique has shown to be efficacious preclinically in the Pollard rat adenocarcinoma model in which micrometastases in the lymph node have been detected, and preliminary studies involving the hamster cheek pouch model in which the pouch is painted with 9, 10 dimethyl-1, 2-benzanthracene (DMBA) for initiation and promotion of tumors. Clinically results will be shown in which fluorescence detection, confirmed by biopsy and histopathological examination, was capable of detecting the existence of micrometastatic involvement of less than 100 cells.!
机译：摘要：微观肿瘤病灶在或超过治疗病灶处的生长在许多癌症的诊断和治疗中构成主要问题。清楚地确定疾病定罪程度或疾病传播范围的早期检测技术可以改善疾病的初级治疗。体内荧光光度法是一种非成像技术，可数字显示相对荧光值（伏特）。该仪器的灵敏度允许在临床前和临床研究中检测微转移，所用药物剂量比治疗剂量低80-90％。该技术目前正用于仓鼠脸颊袋模型的初步实验中，以（1）辨别不同等级的发育异常； （2）在正常生长和静止的肿瘤中药物的吸收水平。结果将显示在两个模型中，其中该技术在Pollard大鼠腺癌模型（其中已检测到淋巴结微转移）的临床上已证明是有效的，并且涉及涉及用小袋涂漆的仓鼠脸颊小袋模型的初步研究9，10二甲基-1，2-苯并蒽（DMBA）用于引发和促进肿瘤。将显示临床结果，其中通过活检和组织病理学检查证实的荧光检测能够检测到少于100个细胞的微转移受累。

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