首页> 外文会议>Pacific Symposium on Biocomputing; 20080104-08; Kohala Coast,HI(US) >AN ANALYSIS OF INFORMATION CONTENT PRESENT IN PROTEIN-DNA INTERACTIONS
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AN ANALYSIS OF INFORMATION CONTENT PRESENT IN PROTEIN-DNA INTERACTIONS

机译:蛋白质-DNA相互作用中信息含量的分析

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Understanding the role proteins play in regulating DNA replication is essential to forming a complete picture of how the genome manifests itself. In this work, we examine the feasibility of predicting the residues of a protein essential to binding by analyzing protein-DNA interactions from an information theoretic perspective. Through the lens of mutual information, we explore which properties of protein sequence and structure are most useful in determining binding residues with a particular focus on sequence features. We find that the quantity of information carried in most features is small with respect to DNA-contacting residues, the bulk being provided by sequence features along with a select few structural features.
机译:了解蛋白质在调控DNA复制中所起的作用,对于完整地了解基因组如何表现自己至关重要。在这项工作中,我们从信息理论的角度分析蛋白质-DNA相互作用,从而检验预测结合必不可少的蛋白质残基的可行性。通过共同的信息,我们探索蛋白质序列和结构的哪些属性在确定结合残基时最有用,尤其着眼于序列特征。我们发现相对于DNA接触残基,大多数特征所携带的信息量很小,其中大部分是由序列特征以及少数几个结构特征提供的。

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