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AN ANALYSIS OF INFORMATION CONTENT PRESENT IN PROTEIN-DNA INTERACTIONS

机译:蛋白质 - DNA相互作用中存在的信息含量分析

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Understanding the role proteins play in regulating DNA replication is essential to forming a complete picture of how the genome manifests itself. In this work, we examine the feasibility of predicting the residues of a protein essential to binding by analyzing protein-DNA interactions from an information theoretic perspective. Through the lens of mutual information, we explore which properties of protein sequence and structure are most useful in determining binding residues with a particular focus on sequence features. We find that the quantity of information carried in most features is small with respect to DNA-contacting residues, the bulk being provided by sequence features along with a select few structural features.
机译:了解角色蛋白在调节DNA复制方面发挥作用对于形成完整的基因组本身的完整图像是必不可少的。在这项工作中,我们通过从信息理论观点分析蛋白质-DNA相互作用来检查预测结合蛋白质的残留物的可行性。通过相互信息的镜片,我们探讨了蛋白质序列和结构的哪个性质在确定具有特别侧序列特征的结合残留物中最有用的。我们发现,在大多数特征中携带的信息量很小,对于DNA接触残留物很小,序列特征和选择少量结构特征的批量提供。

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