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首页> 外文会议>Photonic therapeutics and diagnostics V >Prostate Histotripsy for BPH: Initial Canine Results
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Prostate Histotripsy for BPH: Initial Canine Results

机译：前列腺增生症的前列腺增生症：犬的初步结果

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摘要

Histotripsy is an extracorporeal ablative technology that utilizes microsecond pulses of intense ultrasound (< 1% duty cycle) to produce nonthermal, mechanical fractionation of targeted tissue. We have previously demonstrated the feasibility of histotripsy prostate ablation. In this study we sought to assess the chronic tissue response, tolerability and safety of histotripsy in a chronic in vivo canine model. Five acute and thirteen chronic canine subjects were anesthetized and treated with histotripsy targeting the prostate. Pulses consisted of 3 cycle bursts of 750 kHz ultrasound at a repetition rate of 300 Hz delivered transabdominally from a highly focused 15 cm aperture array. Transrectal ultrasound imaging provided accurate targeting and real-time monitoring of histotripsy treatment. Prostates were harvested at 0, 7, 28, or 56 days after treatment. Consistent mechanical tissue fractionation and debulking of prostate tissue was seen acutely and at delayed time points without collateral injury. Urothelialization of the treatment cavity was apparent 28 days after treatment. Canine subjects tolerated histotripsy with minimal hematuria or discomfort. Only mild transient lab abnormalities were noted. Histotripsy is a promising non-invasive therapy for prostate tissue fractionation and debulking that appears safe and well tolerated without systemic side effects in the canine model.
机译：组织碎裂术是一种体外消融技术，它利用微秒级的强力超声脉冲（占空比小于1％）对目标组织进行非热机械分馏。我们先前已经证明了组织三层前列腺切除术的可行性。在这项研究中，我们试图评估在慢性犬科动物体内模型的慢性组织反应，组织耐受性和安全性。对五名急性和十三名慢性犬科动物进行麻醉，并用针对前列腺的组织曲霉病进行治疗。脉冲由3个750 kHz的超声循环脉冲组成，以300 Hz的重复频率从高度聚焦的15 cm孔径阵列经腹传递。经直肠超声成像可对组织变性治疗提供准确的目标和实时监控。在治疗后0、7、28或56天收获前列腺。观察到一致的机械组织分级分离和前列腺组织减瘤，并且在延迟的时间点没有附带损伤。在治疗后28天，治疗腔的尿道上化明显。犬科动物耐受组织性肌病，血尿或不适感极小。仅观察到轻微的短暂实验室异常。对于小鼠的前列腺组织分级分离和减瘤，组织三联疗法是一种有前途的非侵入性疗法，在犬模型中看起来安全且耐受良好，且无全身性副作用。

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