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首页> 外文会议>Photons Plus Ultrasound: Imaging and Sensing 2007; Progress in Biomedical Optics and Imaging; vol.8 no.14; Proceedings of SPIE-The International Society for Optical Engineering; vol.6437 >Dual wavelength laser diode excitation source for 2D photoacoustic imaging
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Dual wavelength laser diode excitation source for 2D photoacoustic imaging

机译：用于二维光声成像的双波长激光二极管激发源

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摘要

Photoacoustic methods can be used to make spatially resolved spectroscopic measurements of blood oxygenation when using a multiwavelength excitation source, such as an OPO system. Since these excitation sources are usually expensive and bulky, an alternative is to use laser diodes. A fibre coupled laser diode excitation system has been developed, providing two wavelengths, 850 and 905nm, each composed of 6 high peak power pulsed laser diodes. The system provided variable pulse durations (65-500ns) and repetition rates of up to 5KHz. The pulse energies delivered by the excitation system at 905nm and 850nm were measured to be 120μJ and 80μJ respectively for a 200ns pulse duration. To demonstrate the utility of the system, the excitation source was combined with an ultrasound detector to form a probe for in vivo single point measurements of superficial blood vessels. Changes in blood oxygenation and volume in the finger tip were monitored while making venous and arterial occlusions. To demonstrate the imaging capability of the excitation system, 2D photoacoustic images of a physiologically realistic phantom were obtained for a range of pulse durations using a cylindrical scanning system. The phantom was composed of cylindrical absorbing elements(μ_a = 1mm~(-1)) of 2.7mm diameter, immersed in a 1% intralipid solution (μ_s = 1mm~(-1)). This study demonstrated the potential use of laser diodes as an excitation source for photoacoustic imaging of superficial vascular structures.
机译：当使用多波长激发源（例如OPO系统）时，可以使用光声方法对血液氧合进行空间分辨光谱测量。由于这些激发源通常昂贵且笨重，因此替代方案是使用激光二极管。已经开发出一种光纤耦合激光二极管激励系统，它提供两个波长850和905nm，每个波长由6个高峰值功率脉冲激光二极管组成。该系统提供可变的脉冲持续时间（65-500ns）和高达5KHz的重复频率。激发系统在905nm和850nm处传递的脉冲能量在200ns脉冲持续时间内分别为120μJ和80μJ。为了证明该系统的实用性，将激发源与超声检测器组合以形成用于体内浅表血管单点测量的探针。在进行静脉和动脉闭塞时，监测指尖的血液氧合和体积变化。为了证明激发系统的成像能力，使用圆柱扫描系统在一定的脉冲持续时间内获得了生理逼真的体模的2D光声图像。体模由直径为2.7mm的圆柱形吸收元件（μ_a= 1mm〜（-1））组成，并浸入1％脂质溶液中（μ_s= 1mm〜（-1））。这项研究证明了将激光二极管作为激发源用于浅层血管结构的光声成像的潜在用途。

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