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首页> 外文会议>Proceedings of the 18th congress of the International Society for Mushroom Science >Anti-dementia Compounds from the Mushroom Hericium erinaceum
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Anti-dementia Compounds from the Mushroom Hericium erinaceum

机译：蘑菇猴头菇的抗痴呆化合物

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Our group has conducted some studies to search for anti-dementia compounds from medicinal mushrooms since 1991. A series of benzyl alcohol derivatives named as hericenones C to H, as well as a series of diterpenoid derivatives named as erinacines A to I were isolated from the mushroom Hericium erinaceum. These compounds remarkably induced the synthesis of NGF in vitro and/or in vivo. In a recent study, we isolated dilinoleoyl-phosphatidylethanolamine from the mushroom, which protected against neuronal cell death caused by amyloid-peptide toxicity, endoplasmic reticulum (ER) stress, or oxidation stress. Furthermore, the results in clinical trials showed that the mushrrom was effective for patients with dementia
机译：自1991年以来，我们小组进行了一些研究，以从药用蘑菇中寻找抗痴呆化合物。从中提取了一系列名为Hericenones C至H的苄醇衍生物以及一系列名为erinacines A至I的二萜类衍生物。蘑菇猴头菇。这些化合物在体外和/或体内显着诱导了NGF的合成。在最近的研究中，我们从蘑菇中分离出了二亚油酰基-磷脂酰乙醇胺，可防止淀粉样肽毒性，内质网（ER）应激或氧化应激引起的神经元细胞死亡。此外，临床试验结果表明，麝香香菇素对痴呆症患者有效

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