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Fatal Incidence of Humidifier Disinfectants in Korea in 2011: Implications for Risk Management of Biocides of Inhalatory Concern

机译:2011年韩国加湿器消毒剂的致命发病率:对吸入性杀虫剂风险管理的启示

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@@ The Korean Center for Disease Control and Prevention (KCDC) announced on August 31, 2011 that the 'unidentified fatal lung disease' found in Korea might have been caused by chemical disinfectants used with household humidifiers. The impact of the chemical incidence was appalling to the society due to its human fatality by abrupt discovery of the symptom and almost rare recovery by medical treatment. Based on the epidemiological investigation that active ingredients of disinfecting products caused this disease, a subchronic 90-day rat inhalation toxicity testing was conducted with 3 commercial disinfecting products which had been found to be the most commonly consumed ones by the patients and families. By November of 2011, the KCDC and concerned experts concluded that the histopathological readings of human patients, bronchiolar fibrosis, and the ones of rats which inhaled products with polyalkylguanidine moiety are identical and The KCDC ordered recalling all the products containing guanidine moiety.
机译:@@韩国疾病预防控制中心(KCDC)于2011年8月31日宣布,在韩国发现的“身份不明的致命肺部疾病”可能是由家用加湿器使用的化学消毒剂引起的。由于事故的突然发现对人类造成致命性和几乎很少的药物治疗,因此化学事故对社会的影响令人震惊。根据对消毒产品有效成分引起这种疾病的流行病学调查,对3种商业消毒产品进行了亚慢性90天大鼠吸入毒性测试,发现这3种商业消毒产品是患者和家属最常用的产品。到2011年11月,KCDC和有关专家得出的结论是,人类患者,支气管纤维化以及吸入具有聚烷基胍部分产品的大鼠的组织病理学读数相同,KCDC下令召回所有含有胍部分的产品。

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