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首页> 外文会议>Proceedings of Life in space for life on earth >EFFECT OF HYPOXIA AND BEDREST ON PERIPHERAL VASOCONSTRICTION
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EFFECT OF HYPOXIA AND BEDREST ON PERIPHERAL VASOCONSTRICTION

机译：缺氧和床架对周围血管收缩的影响

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摘要

Future planetary habitats may expose astronauts to bothrnmicrogravity and hypobaric hypoxia, both inducing arnreduction in peripheral perfusion. Peripheralrntemperature changes have been linked to sleep onset andrnquality [5]. However, it is still unknown what effectrncombining hypoxia and bedrest has on this relationship.rnEleven male participants underwent three 10-dayrncampaigns in a randomized manner: 1) normobaricrnhypoxic ambulatory confinement (HAmb); 2)rnnormobaric hypoxic bed rest (HBR); 3) normobaricrnnormoxic bed rest (NBR). There was no change in skinrntemperature gradient between the calf and toes, an indexrnof peripheral perfusion (ΔTc-t), over the 10-d period inrnthe HAmb trial. However, there was a significantrnincrease (p< 0.001) in daytime (9am-9pm) ΔTc-t on dayrn10 of the inactivity/unloading periods (HBR and NBRrntrials). This reduction in the perfusion of the toes duringrnthe daytime was augmented during the HBR trialrncompared to NBR (p< 0.001). Before and on day 10 ofrnthe interventions we conducted polysomnographicrnassessment, which revealed no changes in sleep onsetrnand/or architecture. These data support the theory thatrncircadian changes in temperature are functionally linkedrnto sleepiness [1].
机译：未来的行星栖息地可能会使宇航员暴露于微重力和低压缺氧状态下，均会导致外周血灌注减少。周围温度的变化与睡眠发作和质量[5]有关。然而，尚不清楚缺氧与卧床相结合对这种关系有什么影响。十一名男性参与者随机接受了三个为期10天的运动，分别为：1）常压低氧卧床禁闭（HAmb）； 2）常压低氧卧床休息（HBR）; 3）常压常氧卧床休息（NBR）。在HAmb试验的10 d期间，小腿和脚趾之间的皮肤温度梯度没有变化，即外周指数灌注（ΔTc-t）。但是，在闲置/卸载期（HBR和NBRrntrials）的第10天，白天（上午9点至晚上9点）ΔTc-t显着增加（p <0.001）。与NBR相比，在HBR试验期间，白天白天这种脚趾的灌注减少有所增加（p <0.001）。在干预的第10天之前和第10天，我们进行了多导睡眠监测评估，发现睡眠发作和/或结构没有变化。这些数据支持了昼夜节律温度的变化与嗜睡有联系的理论[1]。

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    Adam C. McDonnell; Igor B. Mekjavic; Leja Dolenc-Gro?elj; Polona Jaki Mekjavic; Ola Eiken;

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    Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute Jamova Cesta 39, SI-1000 Ljubljana, Slovenia Jozef Stefan Institute International Postgraduate School, Jamova Cesta 39, SI-1000 Ljubljana, Slovenia adam.mcdonnell@ijs.si;

    Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute Jamova Cesta 39, SI-1000 Ljubljana, Slovenia igor.mekjavic@ijs.si;

    Institute of Neurophysiology, University Clinical Centre Ljubljana, Zalo?ka 4, SI-1000 Ljubljana, Slovenia, leja.dolenc@kclj.si;

    Eye Clinic, University Clinical Centre Ljubljana, Grablovi?eva 46, SI-1000 Ljubljana, Slovenia, Polona Jaki polona.jaki@guest.arnes.si;

    Department of Environmental Physiology, School of Technology and health, Royal Institute of Technology, Berzelius v?g 13, S-171 65 Solna, Sweden, ola.eiken@sth.kth.se;

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