DYNAMIC LIGHT SCATTERING AND RELAXOMETRIC STUDIES OF WATER-SOLUBLE Gd@C_(60) DERIVATIVES AS pH-RESPONSIVE MRI CONTRAST AGENTS

机译：水溶性Gd @ C_（60）衍生物作为pH响应MRI造影剂的动态光散射和相对密度研究

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Derivatized Gd@C_(2n)-based nanomaterials are a promising new class of MRI contrast agent, and recent developments can now provide up to gram quantities of Gd@C_(60) materials for study and evaluation. Gd@C_(60)-based MRI contrast agents potentially offer enhanced safety due to the endohedrally-sequestered metal ion. In this paper, two water-soluble Gd@C_(60) fullerenes, Gd@C_(60)[C(COOH)_2]_(10) and Gd@C_(60)(OH)_x, have been evaluated as pH-responsive contrast agents in vitro. The T_1 relaxivity (R_1) for Gd@C_(60)[C(COOH)_2]_(10) increased by 300% between pH = 10 → 4, while Gd@C_(60)(OH)_x increased by 220%. This phenomenon has been interpreted to arise from slowly tumbling aggregates of the gadofullerenes that increase in size as the pH is lowered.

机译：衍生化的基于Gd @ C_（2n）的纳米材料是一种很有前途的新型MRI造影剂，最近的发展现在可以提供高达克量的Gd @ C_（60）材料用于研究和评估。基于Gd @ C_（60）的MRI造影剂可能会由于内异位金属离子而增强安全性。本文将两种水溶性Gd @ C_（60）富勒烯Gd @ C_（60）[C（COOH）_2] _（10）和Gd @ C_（60）（OH）_x评估为pH体外反应性造影剂。在pH = 10→4时，Gd @ C_（60）[C（COOH）_2] _（10）的T_1弛豫度（R_1）增加300％，而Gd @ C_（60）（OH）_x的T_1弛豫度增加220％。据解释，这种现象是由于随着pH值降低，size富勒烯的聚集体缓慢翻滚而引起的。

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《Proceedings vol.2004-12; Electrochemical Society(ECS) Annual Spring Meeting and International Symposium on Fullerenes, Nanotubes, and Carbon Nanoclusters; 20040509-13; San Antonio,TX(US)》|2004年|P.330-337|共8页
会议地点 San AntonioTX(US)
作者
Balaji Sitharaman; Lon J. Wilson; Robert D. Bolskar; Gabriel Gonzalez; Eva Toth; Lothar Helm; Andre E. Merbach;
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Department of Chemistry and the Center for Nanoscale Science and Technology and the Center for Biological and Environmental Nanotechnology Rice University, MS 60 Houston, Texas 77251-1892, USA;

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正文语种 eng
中图分类无机高分子化合物（高聚物）;
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DYNAMIC LIGHT SCATTERING AND RELAXOMETRIC STUDIES OF WATER-SOLUBLE Gd@C_(60) DERIVATIVES AS pH-RESPONSIVE MRI CONTRAST AGENTS

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