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首页> 外文会议>Prostate cancer imaging : Computer-aided diagnosis, prognosis, and intervention >Automatic MRI Atlas-Based External Beam Radiation Therapy Treatment Planning for Prostate Cancer
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Automatic MRI Atlas-Based External Beam Radiation Therapy Treatment Planning for Prostate Cancer

机译：基于自动核磁共振图谱的前列腺癌外束放射治疗治疗计划

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Prostate radiation therapy dose planning currently requires computed tomography (CT) scans as they contain electron density information needed for patient dose calculations. However magnetic resonance imaging (MRI) images have significantly superior soft-tissue contrast for segmenting organs of interest and determining the target volume for treatment. This paper describes work on the development of an alternative treatment workflow enabling both organ delineation and dose planning to be performed using MRI alone. This is achieved by atlas based segmentation and the generation of pseudo-CT scans from MRI. Planning and dosimetry results for three prostate cancer patients from Calvary Mater Newcastle Hospital (Australia) are presented supporting the feasibility of this workflow. Good DSC scores were found for the atlas based segmentation of the prostate (mean 0.84) and bones (mean 0.89). The agreement between MRI/pseudo-CT and CT planning was quantified by dose differences and distance to agreement in corresponding voxels. Dose differences were found to be less than 2%. Chi values indicate that the planning CT and pseudo-CT dose distributions are equivalent.
机译：前列腺放射治疗剂量规划目前需要计算机断层扫描（CT）扫描，因为它们包含患者剂量计算所需的电子密度信息。但是，磁共振成像（MRI）图像具有明显优越的软组织对比度，可用于分割感兴趣的器官并确定治疗目标体积。本文介绍了开发替代治疗工作流程的工作，该工作流程使仅通过MRI即可进行器官描绘和剂量计划。这可以通过基于图集的分割以及从MRI生成伪CT扫描来实现。提出了来自卡尔弗里·马特·纽卡斯尔医院（澳大利亚）的三名前列腺癌患者的计划和剂量测定结果，证明了该工作流程的可行性。对于基于图集的前列腺（平均0.84）和骨骼（平均0.89）分割，发现了良好的DSC分数。 MRI /伪CT和CT计划之间的一致性通过剂量差异和在相应体素中的一致性距离进行量化。发现剂量差异小于2％。 Chi值表明计划的CT和伪CT剂量分布是等效的。

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