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Separation of Macromolecules by Hexagonal Mesoporous Membrane Filters

机译:六角形介孔膜滤膜分离大分子

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摘要

We fabricated tight mesocylinder silica nanotubes (NTs) inside anodic alumina membrane (AAM) nanochannels as a promising filter candidate for size-exclusion separation of high concentration macromolecules such as lysozyme (LYS), cytochrome c (CytC), myoglobin (Mb), (3-lactoglobulin (P-LG), and hemoglobin (Hb), proteins. The systematic design of the mesocylinder filters was based on densely engineered mesocylinder pores of silica nanotubes (NTs), which are vertically aligned with open surfaces of top-bottom ends inside AAM. The fabricated membranes with impermeable coated layers, robust surfaces, and uniform cylinder pores in nanoscale sizes can rapidly (in seconds) separate large quantities of proteins. Separation of macromolecules could be carried out by bench-top filtration method. This densely engineered mesocylinder filters of macromolecules shows evidence of controlled filtration processes in terms of long-term stability, separation efficiency, and reusability.
机译:我们在阳极氧化铝膜(AAM)纳米通道内制造了紧密的中气柱二氧化硅纳米管(NTs),作为有希望的过滤候选物,用于高浓度大分子如溶菌酶(LYS),细胞色素c(CytC),肌红蛋白(Mb),( 3-乳球蛋白(P-LG)和血红蛋白(Hb)蛋白质。中柱滤池的系统设计基于二氧化硅纳米管(NTs)的密集设计的中柱孔,该孔垂直于上下两端的开口表面对齐在AAM内部,具有不可渗透的涂层,坚固的表面和均匀的纳米级圆柱孔的膜可以快速(数秒)内分离出大量蛋白质,可以通过台式过滤法进行大分子的分离。大分子的中缸过滤器在长期稳定性,分离效率和可重复使用性方面显示出受控过滤过程的证据。

著录项

  • 来源
    《Recent researches in modern medicine》|2011年|p.324-329|共6页
  • 会议地点 Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB)
  • 作者单位

    National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki, 305-0047, JAPAN.,Graduate School for Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, JAPAN;

    National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki, 305-0047, JAPAN.;

    National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki, 305-0047, JAPAN.;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 基础医学;
  • 关键词

    macromolecules; nanotubes; mesocylinder; filter membranes; size-exclusion;

    机译:大分子纳米管中缸滤膜尺寸排他;

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