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Lanthanide-doped nanoparticles for hybrid X-ray/optical imaging

机译:掺杂镧系元素的纳米粒子用于X射线/光学混合成像

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Some lanthanide-doped nanoparticles can absorb X-ray radiation and emit in the visible to near infrared spectrum via a down-conversion mechanism, making them a potentially valuable agent for in vivo imaging studies. We have studied a series of Gd~(3+) and Eu~(3+) compositions in lanthanide fluorides to optimize the emission from Eu~(3+) upon X-ray excitation. The optimum concentration of Eu~(3+) that produced the most intense emission in NaGdF_4 was found to be 15% molar concentration. The impact of the crystallographic phases (i.e. cubic or hexagonal) on the optical emission was investigated. Furthermore, an attempt to include a sensitizer (i.e Ce~(3+)) in NaGdF_4:Eu resulted in a reduction in the emission following X-ray excitation. A surface coating of NaGdF_4:Eu nanoparticles with a gold shell showed a similar decrease in luminescence intensity by a factor of two although the gold shell offers other advantages in biomedical applications.
机译:一些掺杂镧系元素的纳米颗粒可以吸收X射线辐射,并通过下转换机制在可见光到近红外光谱中发射光,这使其成为体内成像研究的潜在有价值的药物。我们研究了镧系元素氟化物中的一系列Gd〜(3+)和Eu〜(3+)组成,以优化X射线激发下Eu〜(3+)的发射。发现在NaGdF_4中产生最强发射的Eu〜(3+)的最佳浓度为15%摩尔浓度。研究了结晶相(即立方或六方晶)对光发射的影响。此外,尝试在NaGdF_4:Eu中包含敏化剂(即Ce〜(3+))导致X射线激发后的发射减少。尽管金壳在生物医学应用中具有其他优势,但带有金壳的NaGdF_4:Eu纳米颗粒的表面涂层显示出相似的发光强度下降两倍。

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