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首页> 外文会议>SPIE Conference on Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications >Lanthanide-doped nanoparticles for hybrid x-ray/optical imaging
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Lanthanide-doped nanoparticles for hybrid x-ray/optical imaging

机译：用于杂交X射线/光学成像的镧系掺杂纳米颗粒

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Some lanthanide-doped nanoparticles can absorb X-ray radiation and emit in the visible to near infrared spectrum via a down-conversion mechanism, making them a potentially valuable agent for in vivo imaging studies. We have studied a series of Gd~(3+) and Eu~(3+)compositions in lanthanide fluorides to optimize the emission from Eu~(3+) upon X-ray excitation. The optimum concentration of Eu~(3+) that produced the most intense emission in NaGdF_4 was found to be 15% molar concentration. The impact of the crystallographic phases (i.e. cubic or hexagonal) on the optical emission was investigated. Furthermore, an attempt to include a sensitizer (i.e Ce~(3+)) in NaGdF4:Eu resulted in a reduction in the emission following X-ray excitation. A surface coating of NaGdF4:Eu nanoparticles with a gold shell showed a similar decrease in luminescence intensity by a factor of two although the gold shell offers other advantages in biomedical applications.
机译：一些镧系掺杂纳米颗粒可以通过下转换机制吸收X射线辐射并在近红外光谱中发射，使其成为体内成像研究的潜在有价值的药剂。我们研究了一系列的Gd〜（3+）和Eu〜（3+）组合物，氟化物中的氟化物氟化物，以优化X射线激发的Eu〜（3+）的发射。发现NAGDF_4中最强烈排放的EU〜（3+）的最佳浓度为15％摩尔浓度。研究了晶体阶段（即立方体或六边形）对光发射的影响。此外，在NAGDF4中试图包括敏化剂（即CE〜（3+））：EU导致X射线激发后发射的减少。 NAGDF4的表面涂层：带金壳的EU纳米粒子显示出同样的发光强度降低两倍，但金壳提供生物医学应用中的其他优点。

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