Preparation and evaluation of nitrendipine nanocrystals

机译：尼群地平纳米晶的制备与评价

获取原文

获取原文并翻译 | 示例

页面导航

摘要
著录项
相似文献
相关主题

摘要

Purpose: To develop a nanocrystal formulation containing nitrendipine nanocrystals for oral delivery. Methods: High pressure homogenization process was employed to prepare the nanocrystals. Results: The prepared nanocrystals significantly improved the solubility and dissolution rate of nitrendipine. The in vivo testing demonstrated that the AUC0→24 of the nanocrystals was approximately 40-fold greater than that of coarse powder. Conclusion: Transformation of nitrendipine coarse powder into nanocrystals is an effective approach to increase the apparent solubility and dissolution rate and, in turn, to enhance the oral bioavailability of nitrendipine.

机译：目的：开发一种含有尼群地平纳米晶体的纳米晶体制剂，用于口服给药。方法：采用高压均质法制备纳米晶。结果：制得的纳米晶体显着提高了尼群地平的溶解度和溶出度。体内测试表明，纳米晶体的AUC0→24约为粗粉的40倍。结论：将尼群地平粗粉转变为纳米晶体是提高表观溶解度和溶解速率，进而提高尼群地平口服生物利用度的有效方法。

著录项

来源
《The Second Asian symposium on pharmaceutical sciences and technology》|2011年|93-94|共2页
会议地点 Xian(CN)
作者
Peng Quan; Dengning Xia; Hongze Piao; Hongyu Piao; Kai Shi; Fude Cui;
展开▼
作者单位

School of Pharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, China;

School of Pharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, China;

School of Pharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, China;

School of Pharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, China;

School of Pharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, China;

School of Pharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, China;

展开▼
会议组织
原文格式 PDF
正文语种 eng
中图分类药剂学;
关键词
Nitrendipine; Nanocrystals; Preparation; Dissolution; Bioavailability.;

机译：硝苯地平；纳米晶体；制备;溶解；生物利用度。;

相似文献

外文文献
中文文献
专利

1. Nitrendipine Nanocrystals: Its Preparation, Characterization, and In Vitro–In Vivo Evaluation [J] . Peng Quan, Dengning Xia, Hongze Piao, AAPS PharmSciTech . 2011,第4期

机译：硝苯地平纳米晶体：其制备，表征和体外评估
2. Preparation and evaluation of solid dispersion for nitrendipine-carbopol and nitrendipine-HPMCP systems using a twin screw extruder. [J] . Wang L, Cui FD, Hayase T, Chemical and Pharmaceutical Bulletin . 2005,第10期

机译：使用双螺杆挤出机制备和评价尼群地平-卡波姆和尼群地平-HPMCP系统的固体分散体。
3. Fabrication, characterization, stability and in vitro evaluation of nitrendipine nanocrystals by media milling [J] . Guo Mengran, Dong Yanjie, Wang Yunzhi, Powder Technology: An International Journal on the Science and Technology of Wet and Dry Particulate Systems . 2019,第期

机译：媒体研磨亚硝基双纳米纳米纳晶体的制造，表征，稳定性和体外评价
4. Preparation and evaluation of nitrendipine nanocrystals [C] . Peng Quan, Dengning Xia, Hongze Piao, Asian symposium on pharmaceutical sciences and technology . 2011

机译：Nitrendipine纳米晶体的制备与评价
5. Decoration of Nanocrystals from Inside-Out: Preparation of Metalated, Doped, and Hybrid Nanocrystals Based on Anatase TiO2 Nanocrystals [D] . ?Mia, Shahzahan 2020

机译：金属化，掺杂的制备和混合基于纳米晶锐钛型二氧化钛纳米晶：从内到外纳米晶装饰
6. Nitrendipine Nanocrystals: Its Preparation Characterization and In Vitro–In Vivo Evaluation [O] . Peng Quan, Dengning Xia, Hongze Piao, 2011

机译：硝苯地平纳米晶体：其制备表征和体外评估
7. Preparation and Evaluation of Solid Dispersion for Nitrendipine-Carbopol and Nitrendipine-HPMCP Systems Using a Twin Screw Extruder [O] . Liang Wang, Fu De Cui, Tomokazu Hayase, 2005

机译：使用双螺杆挤出机的Nitrendipine-Carbopol和Nitrendipine-HPMCP系统的固体分散的制备与评价

Preparation and evaluation of nitrendipine nanocrystals

摘要

著录项

相似文献

相关主题

期刊订阅