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首页> 外文会议>The Second Asian symposium on pharmaceutical sciences and technology >Enhanced stability of insulin by liposomes containing sodium glycocholate in both simulated and endogenous gastrointestinal fluids
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Enhanced stability of insulin by liposomes containing sodium glycocholate in both simulated and endogenous gastrointestinal fluids

机译：在模拟和内源性胃肠液中，含糖胆酸钠的脂质体可增强胰岛素的稳定性

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Purposes: To illustrate the possible mechanism of enhanced oral absorption of insulin (INS) by liposomes containing sodium glycocholate (NaGC-Lip) through the stability evaluation in both simulated and endogenous gastrointestinal fluids.; Methods: The remained INS concentration from NaGC-Lip after incubation in simulated gastrointestinal fluids (SGF, FaSSGF, SIF and FeSSIF-V2) and rats' gastric and intestinal fluids was compared with that from conventional liposomes (CH-Lip).; Results: The remained INS concentration was significantly higher from NaGC-Lip than that from CH-Lip in all tested simulated and endogenous gastrointestinal fluids, which was mainly ascribed to the enzyme-inhibiting ability of sodium glycocholate.; Conclusion: The enhanced in vivo stability of INS from NaGC-Lip was advantageous to the oral delivery of INS.
机译：目的：通过模拟和内源性胃肠液中的稳定性评估，来说明含糖胆酸钠（NaGC-Lip）的脂质体增强胰岛素（INS）口服吸收的可能机制。方法：将NaGC-Lip在模拟胃肠道液（SGF，FaSSGF，SIF和FeSSIF-V2）以及大鼠的胃和肠液中孵育后的剩余INS浓度与常规脂质体（CH-Lip）进行比较。结果：在所有测试的模拟和内源性胃肠液中，NaGC-Lip的残留INS浓度均显着高于CH-Lip，这主要归因于甘露酸钠的酶抑制能力。结论：NaGC-Lip增强了INS的体内稳定性，有利于INS的口服给药。

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