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首页> 外文会议>The Second Asian symposium on pharmaceutical sciences and technology >SCF Particle Design: A High-Tech Platform of DDS Innovation for Strategic Change in The Pharmaceutical Industry
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SCF Particle Design: A High-Tech Platform of DDS Innovation for Strategic Change in The Pharmaceutical Industry

机译：SCF颗粒设计：DDS创新的高科技平台，用于制药行业的战略变革

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摘要

The aim of this work is to prepare stable, small and smart particles with effective formulation for drug delivery system. Hence an attempt is made to develop a high-tech platform of supercritical fluid particle design (SCF PD). Methods employed for SCF PD are based anti-solvent processing, a new type of SCF PD rig was designed and set up, various preparations of chemical or biological drug particles were made with different functional miceo-structures such as nano or micro sized particles, fine powder of specific polymorph, inhaled dry powder and smart composite particles incorporating stabilising agents, characterizations of them were analyzed by SEM, AFM, XRPD, PSA, TGA, DSC, FUR and HPLC. The analytic data shown that all preparations made by SCF PD enhance the dissolution and bioavailability optimize release profiles, as well as improving stability.
机译：这项工作的目的是为药物输送系统制备有效配方的稳定，细小和智能的颗粒。因此，尝试开发一种超临界流体颗粒设计（SCF PD）的高科技平台。用于SCF PD的方法是基于反溶剂处理的，设计并建立了一种新型的SCF PD装置，制备了具有不同功能微结构的化学或生物药物颗粒的各种制剂，例如纳米或微米大小的颗粒，精细特定多晶型物粉末，吸入性干粉和掺入稳定剂的智能复合颗粒，通过SEM，AFM，XRPD，PSA，TGA，DSC，FUR和HPLC分析其特征。分析数据表明，由SCF PD制备的所有制剂均能提高溶出度和生物利用度，从而优化释放特性并提高稳定性。

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  • 来源
  • 会议地点 Xian(CN)
  • 作者

    Yongda Sun; Zhongfeng Geng; Guiming Li; Haoxi Jiang; Minhua Zhang;

  • 作者单位

    Key Laboratory for Green Chemical Technology of Ministry of Education R D Center for Petrochemical Technology, Tianjin University, Tianjin 300072, China;

    Key Laboratory for Green Chemical Technology of Ministry of Education R D Center for Petrochemical Technology, Tianjin University, Tianjin 300072, China;

    Key Laboratory for Green Chemical Technology of Ministry of Education R D Center for Petrochemical Technology, Tianjin University, Tianjin 300072, China;

    Key Laboratory for Green Chemical Technology of Ministry of Education R D Center for Petrochemical Technology, Tianjin University, Tianjin 300072, China;

    Key Laboratory for Green Chemical Technology of Ministry of Education R D Center for Petrochemical Technology, Tianjin University, Tianjin 300072, China;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药剂学;
  • 关键词

    SCF particle design; polymorphism; composite particle; biopharmaceutical particle; DDS;

    机译：SCF颗粒设计；多态性；复合颗粒；生物药物颗粒； DDS;

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