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Selective probes for nicotinic acetylcholine receptros from substituted AE-bicyclic analogs of methyllycacontine

机译：来自甲基甘草精的取代AE-双环类似物的烟碱乙酰胆碱受体的选择性探针

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A concise,kpractical approach to substituted [3.3.1]-AE-bicyclic analogs of methyllycaconitine (MLA) has bene developed employing dianion alkylation and double Mannich reactions.Acetylide anion addition to substituted cyclohexanones and manipulaiton of the acetylide alkoxide dianion genrates sueful bis-propargyl tertiary alcohols.The design adn synthesis of probes for nicotinic acetylcholine receptros (nAChR) affords possible leads for pesticides.MLA also has potential inporbing neuronal nAChR which are implicated in some metchanisms of neurodegeneration.

机译：一种简单，实用的方法，是通过使用二价阴离子烷基化和双重曼尼希反应，开发了取代的[3.3.1] -AE-双环甲基甘可耐碱（MLA）类似物。取代环己酮中乙二醛阴离子的加成和乙炔醇氧基化物二阴离子的手性产生可疑的双-烟酸乙酰胆碱受体（nAChR）探针的设计和合成为农药提供了可能的线索。MLA还具有潜在侵入神经元nAChR的能力，这与某些神经退行性机制有关。

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《Synthesis and chemistry of agrochemicals V》|1997年|p.194-205|共12页
会议地点 San Francisco CA(US)
作者
William J.Trigg; David J.Hardick; Geraldine grangier; Susan Wonnacott; Terrence Lewis; Michael G.Rowan; Barry V.L.Potter; Ian S.Blabrough;
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正文语种 eng
中图分类农业基础科学;
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1. Octahydropyrrolo[3,4-c]pyrrole: A Diamine Scaffold for Construction of Either alpha 4 beta 2 or alpha 7-Selective Nicotinic Acetylcholine Receptor (nAChR) Ligands. Substitutions that Switch Subtype Selectivity [J] . Bunnelle WH, Tietje KR, Frost JM, Journal of Medicinal Chemistry . 2009,第14期

机译：Octahydropyrrolo [3,4-c]吡咯：用于构建α4 beta 2或α7选择性烟碱乙酰胆碱受体（nAChR）配体的二胺支架。切换亚型选择性的取代基
2. Substituted 2-Amìnopyrímidines Selective for α7-Nicotinic Acetylcholine Receptor Activation and Association with Acetylcholine Binding Proteins [J] . Katarzyna Kaczanowska, Gisela Andrea Camacho Hernandez, Larissa Bendiks, Journal of the American Chemical Society . 2017,第10期

机译：对α7-烟碱乙酰胆碱受体活化有选择性并与乙酰胆碱结合蛋白缔合的2-氨基2-啶选择性取代
3. Ligand—receptor interactions in the nicotinic acetylcholine receptor probed using multiple substitutions at conserved tyrosines on the α subunit [J] . Aylwin Maria L., White Michael M. FEBS Letters . 1994,第1期

机译：烟碱乙酰胆碱受体中的配体-受体相互作用，使用α亚基上保守酪氨酸的多个取代进行探测
4. Regulation of Dopamine Release by Striatal Acetylcholine and Nicotine Is via Distinct Nicotinic Acetylcholine Receptors in Dorsal vs. Ventral Striatum [C] . Richard Exley, Michael A. Clements, Stephanie J. Cragg Triennial Meeting of the International Basal Ganglia Society . 2009

机译：通过纹状体乙酰胆碱和尼古丁对多巴胺释放的调节是通过不同的烟碱乙酰胆碱受体在背侧与腹侧纹状体中
5. Structure-Function Studies of Nicotinic Acetylcholine Receptors Using Unnatural Amino Acids and Synthetic Agonist Analogs. [D] . Blum, Angela Patricia. 2012

机译：使用非天然氨基酸和合成激动剂类似物对烟碱乙酰胆碱受体的结构功能研究。
6. Synthesis nicotinic acetylcholine receptor binding in vitro and in vivo pharmacology properties of 3′-(substituted pyridinyl)-deschloroepibatidine analogs [O] . Pauline W. Ondachi, Zhuo Ye, Ana H. Castro, -1

机译：3-（取代的吡啶基）-脱氯表艾巴替丁类似物的合成烟碱乙酰胆碱受体结合体内外药理学性质
7. Substituted 2Aminopyrimidines Selective for 7-Nicotinic Acetylcholine Receptor Activation and Association with Acetylcholine Binding Proteins [O] . -1

机译：取代的2氨基嘧啶选择性7-烟碱乙酰胆碱受体激活和与乙酰胆碱结合蛋白联合
8. Use of Monoclonal Antibodies to Study the Structural Basis of the Function of Nicotinic Acetylcholine Receptors on Electric Organ and Muscle and to Determine the Structure of Nicotinic Acetylcholine Receptors on Neurons. [R] . Lindstrom, J. M. 1989

机译：使用单克隆抗体研究烟碱型乙酰胆碱受体在电活动器官和肌肉上的功能结构基础，并确定神经元上烟碱型乙酰胆碱受体的结构。

Selective probes for nicotinic acetylcholine receptros from substituted AE-bicyclic analogs of methyllycacontine

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