声明
摘要
List of abbreviations
第一章 前言
第二章 材料和方法
第三章 结果
第四章 讨论
研究不足与展望
第五章 结论
参考文献
Section B-The effect of preoperative dose oral gabapentin on perioperative hemodynamic variables and postoperative pain in patients undergoing open abdominal hysterectomy
1．1 Introduction
1．2．Materials and methods
1．3 Results
1．4．Discussion
1．4．1．Discussion
1．4．2 Recommendations
1．5 Conclusion
References
Part 2-Opioid induced hyperalgesia．A review of current evidence，probable mechanism(s) and strategies for treatment
2．1 Introduction
2．2 Definition of OIH
2．3 Historical perspective
2．4 Literature evidence of OIH
2．4．1．Animal data
2．4．2．Former opioid addicts on methadone therapy
2．4．3．Perioperative exposure to opioids
2．4．4．In healthy volunteers using experimental pain models
2．4．5．In chronic pain patients
2．4．6．OIH with very low dose opioids
2．4．7．OIH with very high dose opioids
2．5 Mechanism of opioid action in analgesia
2．6 Mechanism(s) of OIH
2．6．1．Peripheral plasticity
2．6．2．Spinal cord plasticity
2．6．3．Supraspinal plasticity
2．6．4．Genetic influences
2．7 Diagnosis of OIH
2．8 Treatment strategies／modulation of OIH
2．8．1 Treatment strategies
2．8．2 Modulation of OIH
2．9 Conclusion
References
Acknowledgement
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