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首页> 外文学位 >Mind-body medicine epigenetic technique's (MET) potential to modulate ARC and EGR1 (ZIF-268) gene expression in breast cancer patients.
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Mind-body medicine epigenetic technique's (MET) potential to modulate ARC and EGR1 (ZIF-268) gene expression in breast cancer patients.

机译：心身医学表观遗传技术（MET）可能在乳腺癌患者中调节ARC和EGR1（ZIF-268）基因表达。

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摘要

The most common female malignancy worldwide is breast cancer. The estimated death total in the United States for women with breast cancer in 2012 was 39,510. Breast cancer patients struggle with depression, anxiety, and fear as they cope with their diagnosis and prognosis. Depression, anxiety, and fear hinder gene expression supporting memory and learning. Memory and learning support the biology of hope and meaning. Research studies have documented the efficacy of mind-body medicine modalities to modulate gene expression.;The purpose of this research was to review and analyze an archival study on the effects of the Mind-Body Medicine Epigenetic Technique (MET) on arc and EGR1 (zif 268) gene expression in breast cancer patients. Arc and EGR1 (zif-268) gene expression modulate synaptic growth essential for memory and learning. This research study utilized the pre experimental, One-Shot Case Study research design. The gene expression was measured by DNA microarray results using the PrimeviewTM gene chip and PartekRTM Genomics Suite statistical software. For two subjects from Group 1, there were statistically and biologically significant changes in gene expression. Both subjects from Group 1 evidenced biologically and statistically significant up-regulation of EGR1 gene expression. One subject from Group 2 evidenced biologically significant up-regulation of EGR1. There was no biologically and statistically significant up-regulation of arc gene expression in either group. One subject from Group 1 also evidenced biologically significant up regulation of TP53 gene expression and also evidenced the up-regulation of TP53AIP1 gene expression.;Future MET studies could produce stronger statistical and biological significant results with more participants assessed for high levels of cognitive flexibility. This study provided evidence that research subjects with cognitive flexible abilities responded biologically to the MET intervention. In addition to cognitive flexibility, the research subject's ability to maintain and deepen her internal focus is just as essential. These abilities enable the biological response evidenced by gene expression. The body is able to respond to the sustained mental and emotional state of the research subject.;Keywords: Mind-body medicine, meditation, hypnosis, arc gene expression, EGR1 (zif-268) gene expression, memory, learning, breast cancer.
机译：全世界最常见的女性恶性肿瘤是乳腺癌。 2012年，美国乳腺癌女性的估计死亡总数为39,510。乳腺癌患者在应付诊断和预后时会感到沮丧，焦虑和恐惧。抑郁，焦虑和恐惧阻碍了基因表达支持记忆和学习。记忆和学习支持希望和意义的生物学。研究已经记录了心身医学模式调节基因表达的功效。;本研究的目的是回顾和分析关于心身医学表观遗传技术（MET）对电弧和EGR1影响的档案研究（ zif 268）基因在乳腺癌患者中的表达。 Arc和EGR1（zif-268）基因表达调节记忆和学习所必需的突触生长。该研究使用了实验前的一击案例研究设计。使用PrimeviewTM基因芯片和PartekRTM Genomics Suite统计软件通过DNA芯片结果测量基因表达。对于第1组的两名受试者，基因表达存在统计学上和生物学上的显着变化。第一组的两个受试者均在生物学和统计学上证明了EGR1基因表达的显着上调。第2组的一名受试者证明EGR1在生物学上显着上调。两组中弧基因表达均无生物学和统计学上的显着上调。第1组的一名受试者还证明了TP53基因表达的生物学显着上调，并且还证明了TP53AIP1基因表达的上调。未来MET研究可能产生更强的统计和生物学意义，更多的参与者被认为具有较高的认知灵活性。这项研究提供的证据表明，具有认知灵活性的研究对象对MET干预具有生物学反应。除了认知灵活性外，研究对象保持和加深她的内部焦点的能力也同样重要。这些能力使基因表达证明了生物学反应。关键字：身体医学，冥想，催眠，弧基因表达，EGR1（zif-268）基因表达，记忆，学习，乳腺癌。

著录项

  • 作者

    Munoz, Francisco V.;

  • 作者单位

    Saybrook University.;

  • 授予单位 Saybrook University.;
  • 学科 Health sciences.;Genetics.;Oncology.
  • 学位 Ph.D.
  • 年度 2016
  • 页码 92 p.
  • 总页数 92
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 整形外科学（修复外科学）;
  • 关键词

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