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Clinical outcomes of patients with non-small cell lung carcinoma: a retrospective study.

机译：非小细胞肺癌患者的临床结局：一项回顾性研究。

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摘要

Lung carcinoma is the most common cause of cancer mortality worldwide and non-small cell lung carcinoma (NSCLC) accounts for seventy to eighty percent of lung cancer cases. Despite recent advances in therapeutics including personalized treatment based on molecular testing, overall survival of patients diagnosed with NSCLC remains dismal and 70% will die from the disease within the first year following diagnosis. A variety of studies have been conducted to assess the prognostic factors such as age, sex, histological subtype, stage, co-morbidities, smoking status, and treatment regarding NSCLC in attempts to better predict appropriate therapeutic management and also clinical outcomes. Results however have proven to be inconsistent. This retrospective study analyzed patients from the Bassett Medical Center's tumor registry who were diagnosed with NSCLC from 2005-2010. The information from the patient chart reviews was entered into Microsoft access and statistically analyzed to detect differences if any in survival based on sex, age, stage, histological subtype, smoking status, and co-morbidities using the SAS statistical program. Survival curves and log rank tests determined that stage I/II, adenocarcinoma histology, and being female played a role in increased overall survival based on the population given. This corroborates published reports in literature from a rural medical center and may lead to improvement of patient care by providing more individualistic therapeutics as well as providing patients and providers with valuable information that may influence their prognosis. Prior results published on this topic from larger medical centers correlates with these findings among the rural population of Bassett Medical Center, also that overall 5 year survival rates of NSCLC patients of Bassett fits within nationally accepted rates.
机译：肺癌是全世界癌症死亡的最常见原因，非小细胞肺癌（NSCLC）占肺癌病例的70％至80％。尽管包括基于分子测试的个性化治疗在内的治疗方法取得了最新进展，但诊断为NSCLC的患者的总体存活率仍然令人沮丧，并且在诊断后的第一年内将有70％死于该疾病。为了更好地预测适当的治疗方法和临床结果，已经进行了各种研究来评估预后因素，例如年龄，性别，组织学亚型，分期，合并症，吸烟状况以及有关NSCLC的治疗方法。但是，结果证明是不一致的。这项回顾性研究分析了Bassett医学中心肿瘤登记处2005年至2010年诊断为NSCLC的患者。来自患者图表审查的信息已输入Microsoft Access并进行了统计分析，以使用SAS统计程序根据性别，年龄，分期，组织学亚型，吸烟状况和合并症检测生存率差异。生存曲线和对数秩检验确定了I / II期，腺癌的组织学特征以及女性，在给定人群的基础上，在提高整体生存率方面发挥了作用。这证实了来自农村医疗中心的文献中发表的报道，并可能通过提供更具个性化的疗法以及为患者和提供者提供可能影响其预后的宝贵信息而改善患者的护理。大型医疗中心就此主题发表的先前结果与巴塞特医学中心农村人口的这些发现相关，而且巴塞特NSCLC患者的总体5年生存率符合国家认可的水平。

著录项

  • 作者

    Decker, Brandee.;

  • 作者单位

    Albany College of Pharmacy and Health Sciences.;

  • 授予单位 Albany College of Pharmacy and Health Sciences.;
  • 学科 Health Sciences General.;Health Sciences Oncology.;Health Sciences Pathology.
  • 学位 M.S.
  • 年度 2013
  • 页码 49 p.
  • 总页数 49
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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