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首页> 外文学位 >Effect of dietary conjugated linoleic acid on molecular markers for bile acid metabolism, cholesterol synthesis and inflammation in rats.
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Effect of dietary conjugated linoleic acid on molecular markers for bile acid metabolism, cholesterol synthesis and inflammation in rats.

机译：日粮共轭亚油酸对大鼠胆汁酸代谢，胆固醇合成和炎症分子标记的影响。

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Several investigators have shown that dietary conjugated linoleic acid (CLA) reduced atherosclerosis in experimental animals (Wilson et al., 2000; Kritchevsky et al., 2004; Valeille et al., 2004). Although the mechanisms involved in this phenomenon have not been established, reduced de novo cholesterol synthesis, increased bile acid excretion and suppressed inflammation have been implicated. The purpose of the present study was to examine in more detail the potential molecular effects of dietary CLA on regulation of enzymes involved in regulation of cholesterol and bile acid metabolism and to evaluate its influence on markers of inflammation in rats.; CLA refers to a mixture of linoleic acid isomers containing conjugated double bonds and found predominately in foods derived from ruminant animals. Two experiments were conducted in which Wistar rats were fed diets containing butter enriched with CLA or fortified with commercial CLA was compared with corn oil fortified with similar levels of CLA. In the first experiment, feeding CLA to rats resulted in no significant changes in hepatic mRNA levels of key enzymes involved in regulation of cholesterol or bile acid metabolism that could definitively connect CLA's anti-atherosclerotic mechanism to altered cholesterol levels or cholesterol balance. Additionally, no suppression of inflammatory markers was observed. Similar findings were observed in the second experiment in which the diet also contained cholesterol. These results indicated that, in the Wistar rat, CLA does not alter cholesterol balance or inflammation suggesting that observed changes in atherosclerosis are a result of species differences or are due to a mechanism not examined in the present study. However, the impact of dietary CLA appeared to be influenced by the presence of other dietary lipids (butter vs. corn oil) and may warrant further investigation.
机译：几位研究者表明，饮食中的共轭亚油酸（CLA）可降低实验动物的动脉粥样硬化（Wilson等，2000； Kritchevsky等，2004； Valeille等，2004）。尽管尚未建立与这种现象有关的机制，但已暗示了胆固醇从头合成减少，胆汁酸排泄增加和炎症抑制。本研究的目的是更详细地研究膳食CLA对调节胆固醇和胆汁酸代谢相关酶的潜在分子作用，并评估其对大鼠炎症标志物的影响。 CLA是指含有共轭双键的亚油酸异构体的混合物，主要存在于反刍动物的食物中。进行了两个实验，其中给Wistar大鼠饲喂含有富含CLA或商业CLA强化的黄油的饮食，并与添加相似水平CLA的玉米油进行比较。在第一个实验中，给大鼠喂食CLA不会导致参与调节胆固醇或胆汁酸代谢的关键酶的肝mRNA水平发生显着变化，这可以确定地将CLA的抗动脉粥样硬化机制与改变的胆固醇水平或胆固醇平衡联系起来。另外，未观察到炎症标记的抑制。在第二个实验中观察到了相似的发现，其中饮食中也含有胆固醇。这些结果表明，在Wistar大鼠中，CLA不会改变胆固醇的平衡或炎症，这表明所观察到的动脉粥样硬化变化是物种差异的结果，或者是由于本研究中未研究的机制所致。但是，饮食中CLA的影响似乎受到其他饮食脂质（黄油与玉米油）的影响，可能需要进一步研究。

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